|
Schizophrenia
|
0.370 |
Biomarker
|
disease |
BEFREE |
We conclude that dopaminergic signaling is robustly altered in the frontal cortex of VMAT1 null-mutant mice and suggest that VMAT1 may be relevant to the pathogenesis and/or treatment of psychiatric illnesses including schizophrenia and bipolar disease.
|
30685272 |
2019 |
|
Schizophrenia
|
0.370 |
Biomarker
|
disease |
BEFREE |
The gene for solute carrier family 18 member A1 (vesicular monoamine transporter; SLC18A1) is of particular interest in this regard because of its association with schizophrenia, autism and bipolar illness as well as with cancer.
|
30194079 |
2018 |
|
Schizophrenia
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, several recent genetic case-control studies have documented an association between common missense variations in the VMAT1 gene and susceptibility to bipolar disorder and schizophrenia.
|
20419435 |
2010 |
|
Schizophrenia
|
0.370 |
Biomarker
|
disease |
BEFREE |
Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contribute to neuropsychiatric disorders (schizophrenia, autism, bipolar disorder and depression), neurodegenerative disorders (Parkinson's and Alzheimer's disease) and cancer.
|
19204725 |
2009 |
|
Schizophrenia
|
0.370 |
GeneticVariation
|
disease |
LHGDN |
Variations in the VMAT1 gene might affect transporter function and/or expression, and might be involved in the etiology of SZ.
|
18451639 |
2008 |
|
Schizophrenia
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
The gene encoding the vesicular monoamine transporter 1 (VMAT1/SLC18A1) maps to chromosome 8p21, a region where several linkage peaks overlap between schizophrenia, bipolar disorder and anxiety-related personality traits.
|
18249496 |
2008 |
|
Schizophrenia
|
0.370 |
Biomarker
|
disease |
PSYGENET |
Variations in the VMAT1 gene might affect transporter function and/or expression, and might be involved in the etiology of SZ.
|
18451639 |
2008 |
|
Schizophrenia
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Variations in the VMAT1 gene might affect transporter function and/or expression, and might be involved in the etiology of SZ.
|
18451639 |
2008 |
|
Schizophrenia
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Variations in the VMAT1 gene might affect transporter function and/or expression and might be involved in the etiology of BPD and/or SZ.
|
16936705 |
2006 |