SLC22A4, solute carrier family 22 member 4, 6583

N. diseases: 90; N. variants: 21
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.700 Biomarker disease CTD_human
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.700 Biomarker disease HPO
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.500 Biomarker disease GENOMICS_ENGLAND
CUI: C0042384
Disease: Vasculitis
Vasculitis 		0.100 Biomarker disease HPO
CUI: C0497552
Disease: Congenital neurologic anomalies
Congenital neurologic anomalies 		0.100 Biomarker group HPO
CUI: C0850715
Disease: Abnormality of blood and blood-forming tissues
Abnormality of blood and blood-forming tissues 		0.100 Biomarker disease HPO
CUI: C4018871
Disease: Abnormality of the respiratory system
Abnormality of the respiratory system 		0.100 Biomarker disease HPO
CUI: C4021753
Disease: Abnormality of the immune system
Abnormality of the immune system 		0.100 Biomarker disease HPO
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.700 GeneticVariation disease LHGDN An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis. 14608356 2003
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.700 AlteredExpression disease BEFREE Our data indicate that the regulation of SLC22A4 expression by RUNX1 is associated with susceptibility to rheumatoid arthritis, which may represent an example of an epistatic effect of two genes on this disorder. 14608356 2003
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.500 GeneticVariation disease BEFREE The human OCTN1 and OCTN2 orthologs map to the syntenic IBD5 locus at 5q31, which has been shown to confer susceptibility to Crohn's disease. 12535646 2003
CUI: C0003864
Disease: Arthritis
Arthritis 		0.010 AlteredExpression disease BEFREE We show that expression of SLC22A4 is specific to hematological and immunological tissues and that SLC22A4 is also highly expressed in the inflammatory joints of mice with collagen-induced arthritis. 14608356 2003
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.700 Biomarker disease BEFREE Although the association of RUNX1 with RA was identified as a regulatory factor of SLC22A4, it is possible that RUNX1 is a key molecule in autoimmunity, as it has been reported to be associated with systemic lupus erythematosus and psoriasis, two other autoimmune diseases. 15184985 2004
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.700 Biomarker disease LHGDN SLC22A4 and RUNX1: identification of RA susceptible genes. 15184985 2004
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.700 Biomarker disease BEFREE IBD5 and SLC22A4 map to 5q31 and have recently been associated with Crohn's disease and rheumatoid arthritis. 15245375 2004
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.500 GeneticVariation disease BEFREE We validated these candidate genes in Japanese patients with CD and found a weak but possible association with both SLC22A4 (P=0.028) and DLG5 (P=0.023). 15503241 2004
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.500 GeneticVariation disease LHGDN These results suggest that SLC22A4, SLC22A5 and CARD15 act in a common pathogenic pathway to cause Crohn disease. 15107849 2004
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.500 Biomarker disease BEFREE These results suggest that SLC22A4, SLC22A5 and CARD15 act in a common pathogenic pathway to cause Crohn disease. 15107849 2004
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.500 Biomarker disease BEFREE IBD5 and SLC22A4 map to 5q31 and have recently been associated with Crohn's disease and rheumatoid arthritis. 15245375 2004
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.050 Biomarker group BEFREE Although the association of RUNX1 with RA was identified as a regulatory factor of SLC22A4, it is possible that RUNX1 is a key molecule in autoimmunity, as it has been reported to be associated with systemic lupus erythematosus and psoriasis, two other autoimmune diseases. 15184985 2004
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.040 AlteredExpression disease BEFREE Although the association of RUNX1 with RA was identified as a regulatory factor of SLC22A4, it is possible that RUNX1 is a key molecule in autoimmunity, as it has been reported to be associated with systemic lupus erythematosus and psoriasis, two other autoimmune diseases. 15184985 2004
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.030 AlteredExpression disease BEFREE Although the association of RUNX1 with RA was identified as a regulatory factor of SLC22A4, it is possible that RUNX1 is a key molecule in autoimmunity, as it has been reported to be associated with systemic lupus erythematosus and psoriasis, two other autoimmune diseases. 15184985 2004
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.010 GeneticVariation disease BEFREE Haplotype variation at the IBD5/SLC22A4 locus (5q31) in coeliac disease in the Irish population. 15245375 2004
CUI: C0023418
Disease: leukemia
leukemia 		0.010 Biomarker disease BEFREE SLC22A4 is an organic cation transporter with unknown physiological function, and RUNX1 is a hematological transcriptional regulator that has been shown to be responsible for acute myelogenic leukemia. 15184985 2004
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.010 Biomarker disease BEFREE SLC22A4 is an organic cation transporter with unknown physiological function, and RUNX1 is a hematological transcriptional regulator that has been shown to be responsible for acute myelogenic leukemia. 15184985 2004