|
Inflammatory Bowel Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Solute carrier SLC22A4 encodes the carnitine/organic cation transporter OCTN1 and is associated with inflammatory bowel disease, although little is known about how this gene is linked to pathogenesis.
|
30280275 |
2018 |
|
Inflammatory Bowel Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Other studies have found that mutation of rs1143627 of IL1B (allelic model: OR 2.97; 95% CI 1.74-5.05, P < 0.001) and rs1050152 of OCTN1 (allelic model: OR 1.637, 95% CI 1.078-2.485, P = 0.021) increased the proportion of IBD-associated CRC in the population.
|
28243990 |
2017 |
|
Inflammatory Bowel Diseases
|
0.200 |
GeneticVariation
|
group |
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
|
Inflammatory Bowel Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
We found that a turmeric extract and several chromatographically separated fractions beneficially affected the variants of SLC22A4 and IL-10 associated with IBD, by reducing inappropriate epithelial cell transport (SLC22A4, 503F) and increasing anti-inflammatory cytokine gene promoter activity (IL-10, -1082A).
|
25314644 |
2014 |
|
Inflammatory Bowel Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Our data suggest that SNPs and haplotype in the IBD5 SLC22A4/SLC22A5 region contribute to the development of particularly refractory Crohn's disease in the Slovenian population, and expression studies in blood lymphocytes and colon tissue biopsies and eQTL analysis suggest that SLC22A5 is the main gene in the IBD5 region contributing to the IBD pathogenesis.
|
21695374 |
2011 |
|
Inflammatory Bowel Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
To evaluate the association of the IBD5 locus to the predisposition of inflammatory bowel diseases (IBDs), a series of meta-analyses between five IBD5 variants (OCTN1 C1672T, OCTN2 G-207C, OCTN1/2 TC haplotype, IGR2096a_1, IGR2198a_1 and IGR2230a_1) and Crohn's disease (CD) and ulcerative colitis (UC) were performed, which included a total of 26 studies.
|
21279723 |
2011 |
|
Inflammatory Bowel Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
These results indicate that OCTN1 plays a pivotal role for maintenance of systemic and intestinal exposure of ergothioneine, which could be important for protective effects against intestinal tissue injuries, providing a possible diagnostic tool to distinguish the inflammatory bowel diseases.
|
20224991 |
2010 |
|
Inflammatory Bowel Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The OCTN1 rs1050152 is associated with CD (OR=1.745, 95% CI=1.019-2.990, χ²=4.129, p=0.042) and with IBD (OR=1.68, 95% CI=1.052-2.676, χ²=4.732, p=0.030); while the variant rs272879 is not associated with IBD, CD or ulcerative colitis (UC).
|
21122496 |
2010 |
|
Inflammatory Bowel Diseases
|
0.200 |
GeneticVariation
|
group |
LHGDN |
To investigate the single nucleotide polymorphism (SNPs) distribution of NOD2/CARD15 (R702W, G908R), OCTN1 1672C/T and OCTN2-207G/C in Chinese patients with inflammatory bowel disease (IBD).
|
18756601 |
2008 |
|
Inflammatory Bowel Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
To investigate the single nucleotide polymorphism (SNPs) distribution of NOD2/CARD15 (R702W, G908R), OCTN1 1672C/T and OCTN2-207G/C in Chinese patients with inflammatory bowel disease (IBD).
|
18756601 |
2008 |
|
Inflammatory Bowel Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Association of SLC22A4/5 polymorphisms with steroid responsiveness of inflammatory bowel disease in Japan.
|
18274826 |
2008 |
|
Inflammatory Bowel Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
IL23R is an IBD susceptibility gene, but has no epistatic interaction with CARD15 and SLC22A4/5. rs1004819 is the major IL23R variant associated with CD in the German population, while the p.Arg381Gln IL23R variant is a protective marker for CD and UC.
|
17786191 |
2007 |
|
Inflammatory Bowel Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The homozygous mutant OCTN1/2 haplotype was increased in IBD (24.3% v 16.1%, p = 0.02) and UC (28.2% v 16.1%, p = 0.02) compared with controls.
|
16469794 |
2006 |
|
Inflammatory Bowel Diseases
|
0.200 |
GeneticVariation
|
group |
LHGDN |
OCTNs: will the real IBD5 gene please stand up?
|
16773684 |
2006 |
|
Inflammatory Bowel Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
A total of 1104 unrelated Caucasian subjects with inflammatory bowel disease (IBD) (496 CD, 512 UC, 96 indeterminate) and 750 ethnically matched controls were genotyped for three single nucleotide polymorphisms (SNPs) in the CD associated genes (OCTN1+1672, OCTN2-207, and IGR2230), and two flanking IBD5 tagging SNPs, IGR2096 and IGR3096.
|
16361305 |
2006 |
|
Inflammatory Bowel Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Polymorphisms in the organic cation transporter (OCTN) genes SLC22A4 (OCTN1; polymorphism 1672C/T) and SLC22A5 (OCTN2; polymorphism -207G/C) at the inflammatory bowel disease (IBD) 5 locus comprise a two-allele haplotype (SLC22A-TC) associated with increased risk for Crohn's disease (CD).
|
16519742 |
2006 |
|
Inflammatory Bowel Diseases
|
0.200 |
GeneticVariation
|
group |
LHGDN |
We hypothesize that a specific antibody raised to this epitope during C. jejuni or M. paratuberculosis enterocolitis would cross-react with the intestinal epithelial cell functional variant of OCTN1, an already less efficient carnitine transporter, leading to an impairment of mitochondrial beta-oxidation which may then serve as an initiating event in IBD.
|
16246312 |
2005 |
|
Inflammatory Bowel Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The article discusses current information on the relation between CARD15 variants and Crohn disease and the discoveries of SLC22A4/SLC22A5 and DLG5 gene variants that also confer risk for inflammatory bowel disease.
|
15930978 |
2005 |
|
Inflammatory Bowel Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
We hypothesize that a specific antibody raised to this epitope during C. jejuni or M. paratuberculosis enterocolitis would cross-react with the intestinal epithelial cell functional variant of OCTN1, an already less efficient carnitine transporter, leading to an impairment of mitochondrial beta-oxidation which may then serve as an initiating event in IBD.
|
16246312 |
2005 |