Sarcoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Newly discovered uterine sarcoma subtypes include high-grade endometrial stromal sarcomas with BCOR genetic abnormalities, fibrosarcoma-like uterine sarcomas with NTRK rearrangements and COL1A-PDGFRB fusions, as well as undifferentiated uterine sarcomas with SMARCA4 mutations.
|
31846533 |
2020 |
Sarcoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Imaging features of SMARCA4-deficient thoracic sarcomas: a multi-centric study of 21 patients.
|
30762113 |
2019 |
Sarcoma
|
0.400 |
Biomarker
|
group |
BEFREE |
SMARCA4-deficient thoracic sarcoma(DTS) is a recently identified new entity of thoracic malignancies characterized by inactivation of SMARCA4.
|
31097095 |
2019 |
Sarcoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Identification of SMARCA4-deficient uterine sarcomas may be clinically important due to their aggressive behavior, germline association, and emerging targeted therapies.
|
31190001 |
2019 |
Sarcoma
|
0.400 |
Biomarker
|
group |
BEFREE |
In the new review all the tumors were re-classified as, ES (n=16), Ewing-like tumor with EWSR1 rearrangement and amplification and possible EWSR1-NFATC2 gene fusion (n=1), CIC-rearranged sarcomas or undifferentiated sarcoma, most consistent with CIC-rearranged sarcoma (n=7), sarcoma with BCOR-alteration or undifferentiated sarcoma, consistent with BCOR-associated sarcoma (n=3), neuroblastoma (n=2), unclassifiable neoplasm with neuroblastic differentiation (n=1), malignant rhabdoid tumor (n=2), lymphoblastic lymphoma (n=1), clear cell sarcoma of the gastrointestinal tract (n=1), small cell carcinoma (n=1), sclerosing rhabdomyosarcoma (n=1), desmoplastic small round cell tumor (n=1), malignant peripheral sheath nerve tumor (n=1), poorly-differentiated synovial sarcoma (n=1), Possible gastrointestinal stromal tumor/GIST with predominant round cells (n=1) and possible SMARCA4-deficient-sarcoma (n=1).
|
29661713 |
2018 |
Sarcoma
|
0.400 |
Biomarker
|
group |
BEFREE |
We sought to validate the clinicopathological features of SMARCA4-deficient thoracic sarcomas.
|
28643792 |
2017 |
Sarcoma
|
0.400 |
Biomarker
|
group |
BEFREE |
In this study we assessed claudin-4 expression in SWI/SNF complex-deficient neoplasms showing loss of SMARCB1 (INI1), SMARCA4 (BRG1), or ARID1A and other sarcomas with epithelioid morphology.
|
28084340 |
2017 |
Sarcoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Eleven men and one woman with SMARCA4-deficient thoracic sarcomas (aged 27-82 years, median 39 years) were included in the study.
|
28256572 |
2017 |
Sarcoma
|
0.400 |
Biomarker
|
group |
BEFREE |
SMARCA4-deficient thoracic sarcoma: report of a case and insights into how to reach the diagnosis using limited samples and resources.
|
28601660 |
2017 |
Sarcoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
SMARCA4 inactivation defines a group of undifferentiated thoracic malignancies transcriptionally related to BAF-deficient sarcomas.
|
26343384 |
2015 |
Sarcoma
|
0.400 |
Biomarker
|
group |
CTD_human |
The prospective recruitment of cases confirmed this new category of 'SMARCA4-deficient thoracic sarcomas' as readily recognizable in clinical practice, providing opportunities to tailor their therapeutic management.
|
26343384 |
2015 |