Brain Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
SMARCB1-deficient hPSC-derived neural progenitor-like cells (NPLCs) efficiently give rise to brain tumors when transplanted into the mouse brain.
|
30840885 |
2019 |
Brain Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Atypical teratoid/rhabdoid tumors (AT/RTs) are highly malignant brain tumors with inactivation of the SMARCB1 gene, which play a critical role in genomic transcriptional control.
|
31462227 |
2019 |
Brain Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Rare non-rhabdoid brain tumors showing cribriform growth pattern and SMARCB1 loss have been designated cribriform neuroepithelial tumor (CRINET).
|
27380723 |
2017 |
Brain Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We present here a rare case of an adult (35 years) low-grade SMARCB1-deleted brain tumor with transition into prototypical AT/RT over 14 years.
|
28789476 |
2017 |
Brain Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Atypical teratoid/rhabdoid tumors (AT/RT) are rare, aggressive, embryonal brain tumors that occur most frequently in very young children; they are characterized by rhabdoid cells and loss of INI1 protein nuclear expression.
|
26769252 |
2016 |
Brain Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Integrated genomics has identified a new AT/RT-like yet INI1-positive brain tumor subtype among primary pediatric embryonal tumors.
|
26109171 |
2015 |
Brain Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Atypical teratoid/rhabdoid tumor of the brain in an adult with 22q deletion but no absence of INI1 protein: a case report and review of the literature.
|
25909878 |
2015 |
Brain Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we report that altering the genetic background has substantial effects upon MRT development in Snf5(+/--) and TgT121 ;Snf5(+/-) mice, with a mixed F1 background resulting in increased latency and the appearance of brain tumors.
|
23197309 |
2013 |
Brain Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
All high-grade pediatric brain tumors occurring from 1986-2006 at our institution underwent INI-1 IHC.
|
22188464 |
2012 |
Brain Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Atypical teratoid/rhabdoid tumors (AT/RTs) are highly aggressive pediatric brain tumors characterized by the presence of rhabdoid cells and negative immunostaining for INI1 (BAF47).
|
19220299 |
2010 |
Brain Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunohistochemistry with an antibody to INI1 was performed to determine whether this would be a sensitive and specific means of assessing INI1 loss in pediatric brain tumors.
|
15105654 |
2004 |
Brain Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our data suggest that INI1 mutations are involved in the pathogenesis of plexus carcinoma; however, INI1 alterations are not a frequent event in the majority of brain tumor entities.
|
11484819 |
2001 |
Brain Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
These findings suggest that germline mutations in hSNF5 are associated with a novel autosomal dominant syndrome with incomplete penetrance that predisposes to malignant posterior fossa brain tumors in infancy.
|
10739763 |
2000 |