SMO, smoothened, frizzled class receptor, 6608

N. diseases: 215; N. variants: 13
Disease: Basal Cell Cancer ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0751676
Disease: Basal Cell Cancer
Basal Cell Cancer 		0.020 AlteredExpression disease BEFREE Basal cell cancers (BCCs) are characterized by upregulation of Hedgehog pathway through loss of PTCH1 or activation of SMO, and SMO inhibitors, such as vismodegib, are effective therapies for advanced BCCs. 29111235 2018
CUI: C0751676
Disease: Basal Cell Cancer
Basal Cell Cancer 		0.020 GeneticVariation disease BEFREE Some tumors exhibiting hedgehog pathway activation such as basal cell cancer frequently harbor PATCHED-ONE (PTCH-1) or SMOOTHENED (SMO) gene mutations. 18543049 2008