SMS, spermine synthase, 6611

N. diseases: 263; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030193
Disease: Pain
Pain
0.100 Biomarker phenotype BEFREE Oswestry Disability Index and Scoliosis Research Society-22 (SRS-22) pain and self-image at the 2-year follow-up were significantly inferior in the O group (Oswestry Disability Index: 32±9% vs. 25±13%, P=0.01; SRS-22 pain: 3.5±0.7 vs. 3.9±0.6, P=0.05; SRS-22 self-image: 3.5±0.6 vs. 3.8±0.9, P=0.03). 31162180 2020
CUI: C0030193
Disease: Pain
Pain
0.100 Biomarker phenotype BEFREE Information on musculoskeletal pain during the past four weeks in seven different body sites was reported by a structured questionnaire at baseline (n = 389) and by SMS and telephone interview during follow-up (n = 284). 31760469 2020
CUI: C0030193
Disease: Pain
Pain
0.100 Biomarker phenotype BEFREE The following significant associations were found (p<.001): PROMIS Pain Interference is dependent on age and SRS-22r Pain, Physical Function, and Patient Satisfaction; PROMIS Physical Function is dependent on age and SRS-22r Pain and Physical Function; PROMIS Anxiety is dependent on SRS-22r Mental Health; PROMIS Depression is dependent on age and SRS-22r Mental Health; and PROMIS Satisfaction with Social Roles is dependent on age and SRS-22r Pain, Physical Function (p=.011), Mental Health, and Patient Satisfaction. 31525469 2020
CUI: C0030193
Disease: Pain
Pain
0.100 Biomarker phenotype BEFREE A retrospective comparative study using patients' records, radiographs, the national inpatient registry, and Patient-rated outcome measures (PROM): Oswestry disability index (ODI), modif.SRS-24 questionnaire, WHO-Quality of life index (WHOQoL), Numerical rating scale (NRS) for pain. 31375986 2019
CUI: C0030193
Disease: Pain
Pain
0.100 GeneticVariation phenotype BEFREE However, 2 years after the surgery, ODI (38%), pain (3.5), self-image (3.0), and total (3.2) values of the SRS-22 for group NC were significantly worse than those (28%, 4.0, 3.4, and 3.5, respectively) for group C (P < 0.05). 30234799 2019
CUI: C0030193
Disease: Pain
Pain
0.100 GeneticVariation phenotype BEFREE The males had higher scores on the SRS-22r domains function (4.56 vs. 4.42), pain (4.20 vs. 4.00), and mental health (4.14 vs. 3.92) (all P < 0.05). 30180148 2019
CUI: C0030193
Disease: Pain
Pain
0.100 Biomarker phenotype BEFREE Higher functional scores at baseline were associated with greater average improvements in both SRS-22r Activity (B = 0.62, p < 0.001) and PROMIS-PF (B = 0.40, p < 0.001).CONCLUSIONSThe authors found strong correlations between the SRS-22r Pain and Activity domains with corresponding PROMIS-PI and -PF scores. 30797200 2019
CUI: C0030193
Disease: Pain
Pain
0.100 GeneticVariation phenotype BEFREE The websites LivePlanBe, ACI Pain Management Network and MyJointPain top-scored (13/14) from the SMS-14 checklist. 30981410 2019
CUI: C0030193
Disease: Pain
Pain
0.100 Biomarker phenotype BEFREE Higher preoperative Risser grade (P = 0.01) and lower preoperative SRS-22r mental health score (P < 0.01) were significantly related to a diminished preoperative SRS-22r pain score. 31552534 2019
CUI: C0030193
Disease: Pain
Pain
0.100 GeneticVariation phenotype BEFREE Patients were 40- to 80-years-old with ASLS, defined as lumbar coronal Cobb ≥30° and Oswestry Disability Index (ODI) ≥20 or Scoliosis Research Society-22 (SRS-22) ≤4.0 in pain, function, and/or self-image domains. 30921297 2019
CUI: C0030193
Disease: Pain
Pain
0.100 Biomarker phenotype BEFREE In AIS patients pediatric PROMIS pain interference and mobility correlate strongly with SRS-22 pain and function domains, while PROMIS peer relationships demonstrates moderate correlations with SRS-22 mental health and self-image. 31574066 2019
CUI: C0030193
Disease: Pain
Pain
0.100 Biomarker phenotype BEFREE In AIS patients pediatric PROMIS Pain Interference and Mobility correlate strongly with SRS-22 Pain and Function domains, while PROMIS Peer Relationships demonstrates moderate correlations with SRS-22 mental health and self-image. 31205184 2019
CUI: C0030193
Disease: Pain
Pain
0.100 Biomarker phenotype BEFREE There were no significant correlations between limited FFD and SRS-22r or pain visual analog scale scores at 2 years postoperatively. 31361270 2019
CUI: C0030193
Disease: Pain
Pain
0.100 Biomarker phenotype BEFREE According to the other model, a lower improvement in ODI for standing (< 30%; OR 2.68), SRS-22R pain (< 50%; OR 3.25) and SI/appearance (< 50%; OR 2.18) subdomains, and an inadequate restoration of the SVA from baseline (< 2 cm; OR 3.16) were associated with low satisfaction. 31075761 2019
CUI: C0030193
Disease: Pain
Pain
0.100 Biomarker phenotype BEFREE The SRS-30 performed similarly in different pain groups independent of age, gender, or deformity severity. 31106613 2019
CUI: C0030193
Disease: Pain
Pain
0.100 Biomarker phenotype BEFREE SRS-22R questions regarding pain, disability and social and labor function were the most accurately predicted. 31325052 2019
CUI: C0030193
Disease: Pain
Pain
0.100 Biomarker phenotype BEFREE The SRS-22r function, self-image, pain, and mental health scores were moderately to strongly correlated with the following PROMIS domains: physical function (r = 0.53), satisfaction with participation in social roles (r = 0.51), pain (r = -0.60), and anxiety (r = -0.73). 30053523 2019
CUI: C0030193
Disease: Pain
Pain
0.100 Biomarker phenotype BEFREE The SRS-22 self-image score was the most differentiating domain, both in the younger and older age groups, and an additional significant factor in the older age group was pain and disability. 29603012 2018
CUI: C0030193
Disease: Pain
Pain
0.100 Biomarker phenotype BEFREE Considering SRS-22 results, it was revealed that the patient group scored higher, signaling better functioning with reference to pain level (p = 0.016), function/activity (p<0.001) and the total score (p<0.001). 29474440 2018
CUI: C0030193
Disease: Pain
Pain
0.100 Biomarker phenotype BEFREE RESULTS Weak correlations were found between SVA and ODI (r = 0.296, p < 0.05) and PT with NRS back pain and the SRS pain domain (r = -0.260, p < 0.05, and r = 0.282, p < 0.05, respectively). 29570046 2018
CUI: C0030193
Disease: Pain
Pain
0.100 Biomarker phenotype BEFREE After adding respective baseline HRQOL scores to the models, active patients were significantly more likely to reach the MCID for the SRS-22r pain domain (OR 1.72, p = 0.026) and PCS (OR 1.94, p = 0.013). 29624128 2018
CUI: C0030193
Disease: Pain
Pain
0.100 AlteredExpression phenotype BEFREE XPA showed strong correlation to sagittal spinopelvic parameters-PT, SVA, lumbar lordosis (LL), pelvic incidence (PI) minus LL-and to HRQoL scores-ODI, SF-36 PCS and SRS-22 activity and pain. 29330576 2018
CUI: C0030193
Disease: Pain
Pain
0.100 Biomarker phenotype BEFREE The bilateral RF group had less overall improvement in ODI (8.1 vs. 15.8; p=.02), SRS Subscore (0.51 vs. 0.85; p=.03), and SRS Pain domain scores (0.48 vs. 0.95; p=.02) compared with the non-RF group at final follow-up. 29501749 2018
CUI: C0030193
Disease: Pain
Pain
0.100 Biomarker phenotype BEFREE Increased improvement in SRS scores were observed in pain, image, function, and total domains. 28723878 2018
CUI: C0030193
Disease: Pain
Pain
0.100 Biomarker phenotype BEFREE Of the PROs, ODI showed the greatest absolute change from baseline to 2- and 5-year follow-up (2-year Δ 17.6 ± 15.9; 5-year Δ 16.5 ± 19.9) followed by SRS-22r self-image (2-year Δ 1.4 ± 0.96; 5-year Δ 1.3 ± 1.0), pain (2-year Δ 0.94 ± 0.97; 5-year Δ 0.80 ± 1.0), function (2-year Δ 0.60 ± 0.62; 5-year Δ 0.49 ± 0.79), and mental health (2-year Δ 0.49 ± 0.77; 5-year Δ 0.38 ± 0.84). 29979138 2018