|
Schizophrenia
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
To identify common variants in SNAP25 associated with schizophrenia and evaluate their effects on AIWG and antipsychotic responses in Han Chinese individuals with schizophrenia, we conducted a two-stage case-control study of 3,243 patients and 6,154 healthy controls.
|
31653583 |
2020 |
|
Schizophrenia
|
0.300 |
Biomarker
|
disease |
BEFREE |
Among the results, we found a significant reduction in synaptophysin in schizophrenia in the hippocampus (effect size: -0.65, p < 0.01), frontal (effect size: -0.36, p = 0.04), and cingulate cortices (effect size: -0.54, p = 0.02), but no significant changes for synaptophysin in occipital and temporal cortices, and no changes for SNAP-25, PSD-95, VAMP, and syntaxin in frontal cortex.
|
29511299 |
2019 |
|
Schizophrenia
|
0.300 |
Biomarker
|
disease |
BEFREE |
Lower ARF1-21 levels were associated with the previously reported increased SNAP25-syntaxin interaction in schizophrenia (r = -0.39, P = 0.04).
|
30610939 |
2019 |
|
Schizophrenia
|
0.300 |
Biomarker
|
disease |
BEFREE |
Reduced SNAP25 Protein Fragmentation Contributes to SNARE Complex Dysregulation in Schizophrenia Postmortem Brain.
|
30579835 |
2019 |
|
Schizophrenia
|
0.300 |
Biomarker
|
disease |
BEFREE |
The PRS for SCZ and SNAP-25-associated genes could not explain the variance of neurocognition in this cohort.
|
30523404 |
2018 |
|
Schizophrenia
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Thus, the present study investigated the associations between polymorphisms of SNAP25 and the treatment response to amisulpride in patients with schizophrenia.
|
28947383 |
2017 |
|
Schizophrenia
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our findings provide <i>in vivo</i> functional evidence showing a critical role of SNAP-25 dysfunction on synaptic transmission, which contributes to the developmental of schizophrenia.
|
29318050 |
2017 |
|
Schizophrenia
|
0.300 |
Biomarker
|
disease |
BEFREE |
The synaptosomal-associated protein SNAP25 is a key player in synaptic vesicle docking and fusion and has been associated with multiple psychiatric conditions, including schizophrenia, bipolar disorder, and attention-deficit/hyperactivity disorder.
|
28972123 |
2017 |
|
Schizophrenia
|
0.300 |
Biomarker
|
disease |
BEFREE |
Thus, we investigated the association between SNAP25 and both schizophrenia and major depressive disorder in the Han Chinese population.
|
25650683 |
2015 |
|
Schizophrenia
|
0.300 |
Biomarker
|
disease |
BEFREE |
Synaptosomal-associated protein of 25 kDa (SNAP-25) is involved in different neuropsychiatric disorders, including schizophrenia and attention-deficit/hyperactivity disorder.
|
25629685 |
2015 |
|
Schizophrenia
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Association was also evaluated by considering the polymorphisms as interactions; in this case, a likelihood ratio test (LRT) revealed evidence for association with schizophrenia in four polymorphism combinations: two DRD3*SNAP-25 combinations (rs6280*rs3746544 and rs6280*rs3746544, P=0.02), one ADRA2A*SNAP25 combination (rs1800544*rs3746544) and one ADRA2A*DBH combination (rs1800544*rs2519152).
|
22940547 |
2013 |
|
Schizophrenia
|
0.300 |
Biomarker
|
disease |
BEFREE |
Notably, SNAP-25 has been implicated in schizophrenia from genetic [5-8], pathological [9-13], and functional studies [14-16].
|
22264613 |
2012 |
|
Schizophrenia
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
SNAP25 is crucial to synaptic functioning, may be involved in axonal growth and dendritic sprouting, and its expression may be decreased in schizophrenia.
|
19806613 |
2010 |
|
Schizophrenia
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Post hoc analysis revealed that the SNPs nominally associated with schizophrenia (rs3787283, rs3746544) were the same as those previously demonstrated to be associated with ADHD but with the opposite alleles, allowing the intriguing hypothesis that genetic variation at SNAP25 may be differentially associated with both schizophrenia and ADHD.
|
19132710 |
2009 |
|
Schizophrenia
|
0.300 |
Biomarker
|
disease |
BEFREE |
Several post mortem studies revealed a reduction of SNAP-25 protein in the hippocampus of patients with schizophrenia and bipolar disorder (BD).
|
18726138 |
2008 |
|
Schizophrenia
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We conducted a two-stage genetic association analysis of Syntaxin1A (STX1A), VAMP2 and SNAP25 genes with schizophrenia (first-set screening samples: 377 cases and 377 controls, second-set confirmation samples: 657 cases and 527 controls).
|
18512733 |
2008 |
|
Schizophrenia
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
As neurocognitive impairment is a core feature in the pathology of schizophrenia and considered to be a putative endophenotype according to genetic studies we investigated the influences of different SNAP-25 polymorphisms on neuropsychological test results before and during treatment with atypical antipsychotics.
|
18347838 |
2008 |
|
Schizophrenia
|
0.300 |
Biomarker
|
disease |
MGD |
A dominant mutation in Snap25 causes impaired vesicle trafficking, sensorimotor gating, and ataxia in the blind-drunk mouse.
|
17283335 |
2007 |
|
Schizophrenia
|
0.300 |
Biomarker
|
disease |
BEFREE |
The SNAP-25 gene may be associated with clinical response and weight gain in antipsychotic treatment of schizophrenia.
|
15823421 |
2005 |
|
Schizophrenia
|
0.300 |
Biomarker
|
disease |
LHGDN |
We previously demonstrated increased synaptosomal associated protein, 25 kDa (SNAP-25), a member of the exocytotic mechanism, in the cerebrospinal fluid (CSF) of schizophrenia subjects.
|
12814864 |
2003 |
|
Schizophrenia
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that polymorphisms in the 5'-upstream region of the SNAP-25 gene have no association with schizophrenia.
|
11287790 |
2001 |
|
Schizophrenia
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
These alterations in tissue levels of synaptophysin and SNAP-25 are consistent with the idea that the clinically observed 'hypofrontality' of schizophrenia arises from abnormalities of synaptic number or structural integrity in prefrontal cortex.
|
10089007 |
1999 |