Attention deficit hyperactivity disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Swanson, Nolan, and Pelham Scale for ADHD Version IV (SNAP-IV) was used to evaluate behavioral symptoms and the Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV) and the Conners' Continuous Performance Test (CPT) were utilized to assess neurocognitive functions.
|
30711898 |
2019 |
Attention deficit hyperactivity disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results show that Cdk5, TrkB, STX1A, and SNAP25 were involved in the modulation of MPH effects in prefrontal cortex of SHRs and play important role in treatment of ADHD.
|
31352739 |
2019 |
Attention deficit hyperactivity disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Dose titrations of central stimulants in 56 children with ADHD were evaluated using QbTest and the Swanson, Nolan, Pelham, version IV (SNAP-IV) scale.
|
30452083 |
2019 |
Attention deficit hyperactivity disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The current findings provide new insights into the underlying neural mechanisms linking SNAP-25 rs3746544 with the risk for ADHD via the endophenotype of brain functional connectivity.
|
30092259 |
2018 |
Attention deficit hyperactivity disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
For the whole sample, the primary outcomes (parent-rated ADHD on the Swanson, Nolan, and Pelham [SNAP] scale and noncompliance on the Home Situations Questionnaire [HSQ]) deteriorated mildly from week 34 to FU, but were still substantially better than baseline (SNAP: t = 12.177, df = 93, p < 0.001; HSQ: t = 8.999, df = 93, p < 0.001).
|
29694241 |
2018 |
Attention deficit hyperactivity disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest the possible involvement of the <i>SNAP-25</i> 1065 T>G polymorphism in the inattention phenotype in children with ADHD.
|
28783930 |
2017 |
Attention deficit hyperactivity disorder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Decreased expression of SNAP-25 is associated with Alzheimer's disease and attention deficit/hyperactivity disorder.
|
28761431 |
2017 |
Attention deficit hyperactivity disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We tested the association between ADHD and polymorphisms on the SNARE genes STX1A (rs2228607), SYT1 (rs1880867 and rs2251214), VAMP2 (26bp Ins/Del) and SNAP25 (rs6108461 and rs8636) on a sample comprised of 548 adults with ADHD and 644 non-affected controls.
|
28130000 |
2017 |
Attention deficit hyperactivity disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Parents/caregivers and teachers responded to the Swanson, Nolan and Pelham scale - version IV (SNAP-IV) for the assessment of ADHD signs.
|
28155241 |
2017 |
Attention deficit hyperactivity disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we analyzed the possible association between six polymorphisms (rs3746544, rs363006, rs1051312, rs8636, rs362549, and rs362998) of SNAP25 and ADHD in a pooled sample of ten family-based studies and four case-control studies by using meta-analysis.
|
26941099 |
2017 |
Attention deficit hyperactivity disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus, the present study aimed to determine the relationship between changes in creatine (Cr), choline (Cho), and N-acetyl aspartate (NAA) levels in the prefrontal cortex (PFC) and anterior cingulate cortex (ACC) of adults with ADHD and the SNAP-25 gene polymorphism following the use of MPH.
|
27338073 |
2016 |
Attention deficit hyperactivity disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that SNAP25 and NOS1 genotypes influence ADHD symptoms only in adults with ADHD.
|
26821215 |
2016 |
Attention deficit hyperactivity disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Further investigations with larger populations are needed in order to clarify the exact role of SNAP-25 variations in susceptibility to ADHD.
|
27627841 |
2016 |
Attention deficit hyperactivity disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
We genotyped eight single nucleotide polymorphisms (SNP) of Syntaxin 1A (STX1A), vesicle-associated membrane protein 2 (VAMP2) and synaptosomal-associated protein 25 kDa (SNAP25) and conducted case-control studies in 1404 male ADHD and 617 male controls.
|
25445064 |
2015 |
Attention deficit hyperactivity disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Synaptosomal-associated protein of 25 kDa (SNAP-25) is involved in different neuropsychiatric disorders, including schizophrenia and attention-deficit/hyperactivity disorder.
|
25629685 |
2015 |
Attention deficit hyperactivity disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Many previous studies have reported the SNAP25 gene to be significantly associated with attention-deficit/hyperactivity disorder (ADHD).
|
25650683 |
2015 |
Attention deficit hyperactivity disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Problems associated with the noradrenergic and serotonergic systems and SNAP-25 may play a role, both alone and in interaction with one another, in the pathophysiological mechanisms of ADHD.
|
23872233 |
2013 |
Attention deficit hyperactivity disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
ADHD symptom dimensions were investigated with SNAP-IV for ADHD severity and Barkley scales for severity and impairment.
|
22584804 |
2013 |
Attention deficit hyperactivity disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the present investigation, for the first time association between ADHD and six SNAP25 polymorphisms, rs1889189, rs362569, rs362988, rs3746544, rs1051312, and rs8636 was explored in eastern Indian population.
|
21996783 |
2012 |
Attention deficit hyperactivity disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
To date, these studies have reported substantial evidence implicating several genes (dopaminergic: DRD4, DAT1, DRD5, COMT; noradrenergic: DBH, ADRA2A; serotonergic: 5-HTT, HTR1B, HTR2A; cholinergic: CHRNA4, and central nervous system development pathway: SNAP25, BDNF) in the etiology of ADHD.
|
22825876 |
2012 |
Attention deficit hyperactivity disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggested that SNAP-25 polymorphism might be associated with methylphenidate induced brain hemodynamic changes in ADHD participants.
|
20679152 |
2011 |
Attention deficit hyperactivity disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
This is the first report of an association between SNAP-25 and ADHD in Chinese subjects of Han descent.
|
20599404 |
2011 |
Attention deficit hyperactivity disorder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Both reduced and excessive SNAP-25 activity has been implicated in various disease states that involve cognitive dysfunctions such as attention deficit hyperactivity disorder, schizophrenia and Alzheimer's disease.
|
20002519 |
2010 |
Attention deficit hyperactivity disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
SNPs in seven genes including SLC1A3, SLC6A3, HTR4, ADRA1A, HTR2A, SNAP25, and COMT showed a nominal level of association with ADHD (P values <0.05), but none remained significant after a stringent correction for the total number of tests performed.
|
19352218 |
2009 |
Attention deficit hyperactivity disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Consistent with ADHD being a developmental disorder, animal models are either genetic (spontaneously hypertensive rats (SHR), dopamine transporter (DAT) knock-out mice, SNAP-25 mutant mice, mice expressing a mutant thyroid receptor) or have suffered an insult to the central nervous system during the early stages of development (anoxia, 6-hydroxydopamine).
|
17980763 |
2007 |