|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Alpha-synuclein (alpha-syn) protein and a fragment of it, called NAC, have been found in association with the pathological lesions of a number of neurodegenerative diseases.
|
9862428 |
1998 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Alpha-synuclein (alpha-syn) protein has been found in association with the pathological lesions of a number of neurodegenerative diseases.
|
9862427 |
1998 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The identification of novel alpha-synuclein-immunoreactive bands in these various forms of parkinsonism may open new research avenues for exploring the relationship between abnormal protein deposition in the brain and one or more neurodegenerative disorders, including the Contursi form of familial parkinsonism.
|
9878203 |
1998 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Alpha synuclein has been specifically implicated in neurodegenerative disease.
|
10491577 |
1999 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Parkinson's disease (PD) is a neurodegenerative disorder that is pathologically characterized by the presence of intracytoplasmic Lewy bodies, the major component of which are filaments consisting of alpha-synuclein.
|
10092675 |
1999 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
alpha-Synuclein is a soluble presynaptic protein which is pathologically redistributed within intracellular lesions characteristic of several neurodegenerative diseases.
|
10075647 |
1999 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Parkinson's disease (PD) is a neurodegenerative disorder that is pathologically characterized by the presence of intracytoplasmic Lewy bodies, the major components of which are filaments consisting of alpha-synuclein.
|
10391881 |
1999 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Increasing knowledge on the pathogenic molecular mechanisms of neurodegeneration and of the pathophysiological function of alpha-synuclein in particular may influence future development of therapeutic strategies in neurodegenerative disorders.
|
10809401 |
2000 |
|
Neurodegenerative Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Altogether, our study indicates that wild-type alpha-synuclein exerts an antiapoptotic effect in neurons that appears to be abolished by the Parkinson's disease-related mutation, thereby suggesting a possible mechanism underlying both sporadic and familial forms of this neurodegenerative disease.
|
10818098 |
2000 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Consequently, abnormal transport, metabolism or function of NACP/alpha-synuclein appears to impair synaptic function, which induces, at least in part, neuronal degeneration in several neurodegenerative diseases.
|
10899435 |
2000 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
To address the role of alpha-synuclein in neurodegenerative diseases, we performed a yeast two-hybrid screen of a rat adult brain cDNA library using rat alpha-synuclein 2 (alphaSYN2).
|
11032911 |
2000 |
|
Neurodegenerative Disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The synucleins (alpha, beta, and gamma) are a family of small cytoplasmic proteins that are expressed predominantly in neurons. alpha synuclein has attracted considerable attention due to its involvement in neurodegenerative diseases.
|
10813729 |
2000 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The involvement of alpha-synuclein in neurodegenerative diseases was first suspected after the isolation of an alpha-synuclein fragment (NAC) from amyloid plaques in Alzheimer's disease (AD).
|
11215516 |
2000 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
alpha-Synuclein has been centrally implicated in neurodegenerative disease, and a normal function in developmental synaptic plasticity has been suggested by studies in songbirds.
|
10952980 |
2000 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
However, there is growing evidence that neuronal apoptosis in the absence of obvious pathological deposits could have a serious impact on the pathogenesis of neurodegenerative diseases. alpha-Synuclein has been implicated in aetiology and pathogenesis of certain neurodegenerative diseases, although the precise role of this protein in neurodegeneration is uncertain.
|
10971650 |
2000 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders.
|
10678833 |
2000 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The toxicity of alpha-synuclein and related peptides towards neurons is also discussing in relation to the aetiology of neurodegenerative diseases.
|
10940234 |
2000 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The synucleinopathies are a diverse group of neurodegenerative disorders that share a common pathologic lesion composed of aggregates of insoluble alpha-synuclein protein in selectively vulnerable populations of neurons and glia.
|
11176955 |
2001 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
However, epitope mapping for alpha-synuclein is distinctive in different neurodegenerative diseases.
|
11708989 |
2001 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin.
|
11431533 |
2001 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
From genetics to pathology: tau and alpha-synuclein assemblies in neurodegenerative diseases.
|
11260802 |
2001 |
|
Neurodegenerative Disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Although alpha-synuclein is expressed primarily in neurons, it is a major component of oligodendroglial and astrocytic inclusions in several neurodegenerative diseases.
|
11435921 |
2001 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
alpha-Synuclein has risen to prominence during the past 5 years because of its association with several neurodegenerative diseases that have come to be known as the synucleinopathies.
|
11470957 |
2001 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The significance of tau and alpha-synuclein inclusions in neurodegenerative diseases.
|
11377973 |
2001 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The role of alpha-synuclein in glial cells and its relevance to the molecular pathology of neurodegenerative diseases is presently unclear.
|
11536327 |
2001 |