|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
<b>Areas covered</b>: Bis-heteroaryl derivatives based on the <i>N</i>-[1-(1<i>H</i>-indol-3-yl)hexan-2-yl]-1,3-thiazole-5-carboxamide scaffold with different heterocyclic substitutions at the 2-thiazole position showed interesting ability to inhibit self-aggregation of α-synuclein <i>in vitro</i> and were claimed as potential therapeutics for various neurodegenerative diseases.
|
30359535 |
2018 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Neurodegenerative diseases classified as synucleinopathies are characterized by alpha-synuclein inclusions.
|
15581183 |
2004 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Neurodegenerative disorders such as Parkinson's Disease (PD), PD dementia (PDD) and Dementia with Lewy bodies (DLB) are characterized by progressive accumulation of α-synuclein (α-syn) in neurons.
|
28086964 |
2017 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Neurodegenerative disorders (NDs) are characterized by abnormal accumulation/misfolding of specific proteins, primarily α-synuclein (α-syn), β-amyloid<sub>1-42</sub> (Aβ), and tau, in both brain and peripheral tissue.
|
28421539 |
2018 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Neurodegenerative disorders (NDs) are characterized by abnormal accumulation/misfolding of specific proteins, primarily α-synuclein (α-syn), β-amyloid<sub>1-42</sub> (Aβ<sub>1-42</sub>) and tau, in both brain and peripheral tissues.
|
29520218 |
2018 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Neurodegenerative disorders of the aging population are characterized by progressive accumulation of neuronal proteins such as α-synuclein (α-syn) in Parkinson's Disease (PD) and Amyloid ß (Aß) and Tau in Alzheimer's disease (AD) for which no treatments are currently available.
|
30849508 |
2019 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
alpha-Synuclein is a soluble presynaptic protein which is pathologically redistributed within intracellular lesions characteristic of several neurodegenerative diseases.
|
10075647 |
1999 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Alpha synuclein has been specifically implicated in neurodegenerative disease.
|
10491577 |
1999 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
alpha-Synuclein has been centrally implicated in neurodegenerative disease, and a normal function in developmental synaptic plasticity has been suggested by studies in songbirds.
|
10952980 |
2000 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
alpha-Synuclein has risen to prominence during the past 5 years because of its association with several neurodegenerative diseases that have come to be known as the synucleinopathies.
|
11470957 |
2001 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
alpha-Synuclein has been implicated in the pathogenesis of Parkinson disease (PD) and related neurodegenerative disorders.
|
12239163 |
2002 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
LHGDN |
Alpha-synuclein (alpha-syn) and tau polymerize into amyloid fibrils and form intraneuronal filamentous inclusions characteristic of neurodegenerative diseases.
|
12714745 |
2003 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Alpha-synuclein: its biological function and role in neurodegenerative diseases.
|
12794302 |
2003 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Alpha-synuclein is a major component of several pathological lesions diagnostic of specific neurodegenerative disease such as Parkinson's disease.
|
16081040 |
2005 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Alpha-synuclein (alphaSyn) misfolding is associated with several devastating neurodegenerative disorders, including Parkinson's disease (PD).
|
16794039 |
2006 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Alpha-synuclein has been implicated in the pathology of certain neurodegenerative diseases, including Parkinson disease (PD) and dementia with Lewy bodies (LBs).
|
17337120 |
2007 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Alpha-synuclein is involved in dopaminergic neurotransmission and has been implicated in a number of neurodegenerative disorders, such as Parkinson's disease.
|
17374033 |
2007 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
alpha-Synuclein is a primarily neuronal protein that is enriched at the pre-synapse. alpha-Synuclein and the microtubule binding protein tau have been implicated in neurodegenerative diseases. alpha-Synuclein is known to associate with phospholipid vesicles, regulates dopamine metabolism and exhibits chaperone activity, but its main role remains largely unknown.
|
17408955 |
2007 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Alpha-synuclein has been implicated in the pathology of certain neurodegenerative diseases, including Parkinson disease (PD).
|
18061619 |
2008 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Alpha-synuclein (alpha-syn) has been implicated in the pathogenesis of many neurodegenerative disorders, including Parkinson's disease.
|
18322092 |
2008 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Alpha-synuclein (alphaSN) plays a major role in numerous neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease.
|
18355641 |
2008 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
alpha-Synuclein (alpha-syn) is the major component of pathologic inclusions that characterize neurodegenerative disorders such as Parkinson disease, dementia with Lewy body disease, and multiple system atrophy.
|
18451726 |
2008 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Alpha-synuclein is an abundant presynaptic brain protein, misfolding, aggregation and fibrillation of which are implicated as critical factors in several neurodegenerative diseases.
|
18855701 |
2008 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Alpha-synuclein remains a protein of interest due to its propensity to form fibrillar aggregates in neurodegenerative disease and its putative function in synaptic vesicle regulation.
|
19126542 |
2009 |
|
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Alpha-synuclein (alpha-syn) amyloid filaments are the major ultrastructural component of pathological inclusions that define several neurodegenerative disorders, including Parkinson disease and other disorders that are collectively termed synucleinopathies.
|
20026050 |
2010 |