|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We first constructed an α-synuclein-overexpressed human neuroblastoma cell line, SH-SY5Y-Syn(+), stably over-expressing wild-type α-synuclein and sensitive to an autophagy inhibitor, which exerted no effect on the expression of LAMP2A and Hsc 70.
|
25207598 |
2014 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We used neuroblastoma SH-SY5Y cell line and rat synaptoneurosomes treated with exogenous soluble ASN.
|
28516276 |
2017 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
WT alpha-synuclein was stably overexpressed in human BE(2)-M17 neuroblastoma cells resulting in increased levels of an alpha-synuclein multimer, but no increase in alpha-synuclein monomer levels.
|
28620826 |
2017 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we discover aberrant HSF1 degradation by aggregated α-synuclein (or α-synuclein-induced proteotoxic stress) in transfected neuroblastoma cells.
|
26503960 |
2016 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Microarray expression analysis of human dopaminergic neuroblastoma cells after RNA interference of SNCA--a key player in the pathogenesis of Parkinson's disease.
|
19135032 |
2009 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the present study, the effect of alpha-synuclein overexpression on GJIC in human dopaminergic neuroblastoma SH-SY5Y cells was investigated.
|
17337120 |
2007 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have probed the mechanism of neurotoxicity of α-synuclein oligomers isolated in vitro using antibodies targeting the N-terminal region of the protein and found that the presence of the antibody resulted in a substantial reduction of the damage induced by the aggregates when incubated with primary cortical neurons and neuroblastoma cells.
|
31050886 |
2019 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Tissue transglutaminase is not involved in the aggregate formation of stably expressed alpha-synuclein in SH-SY5Y human neuroblastoma cells.
|
15460447 |
2004 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We then used a human neuroblastoma cells (M17) stably over-expressing alpha-synuclein and found that RAC1 function decreased the amount of amyloidogenic alpha-synuclein.
|
29429047 |
2018 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The oxysterol 27-hydroxycholesterol regulates α-synuclein and tyrosine hydroxylase expression levels in human neuroblastoma cells through modulation of liver X receptors and estrogen receptors--relevance to Parkinson's disease.
|
21951066 |
2011 |
|
Neuroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Finally, we show that this association inhibits α-synuclein A53T oligomer toxicity in neuroblastoma cells.
|
28102321 |
2017 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data indicate that the uptake-mediated accumulation of αSyn in a human-derived neuroblastoma cell line triggered an adaptive response that involved proteins linked to ubiquitin ligases of the S-phase kinase-associated protein 1 (SKP1), cullin-1 (Cul1), and F-box domain-containing protein (SCF) family.
|
31167929 |
2019 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Heat shock protein 70 induction by glutamine increases the α-synuclein degradation in SH-SY5Y neuroblastoma cells.
|
26135068 |
2015 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The conjugates were found to be have low cytotoxicity and reduced toxicity of α-Syn toward SH-SY5Y neuroblastoma cells.
|
30968030 |
2019 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here we show that recombinant expression of alpha-synuclein in human neuroblastoma cells enhances cellular levels of PLCβ1 but blunts its signaling pathway, preventing the agonist-dependent rise of cytoplasmic Ca<sup>2+</sup>.
|
27871937 |
2017 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Differential cytotoxicity of dopamine and H2O2 in a human neuroblastoma divided cell line transfected with alpha-synuclein and its familial Parkinson's disease-linked mutants.
|
12727333 |
2003 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We show, using a pH-sensitive probe, that internalization of α-synuclein amyloid fibrils in neuroblastoma cells is dependent on heparan sulfate, whereas internalization of smaller non-amyloid oligomers is not.
|
28827536 |
2017 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, treatment of the hit compounds significantly reduced the α-synuclein expression in SH-SY5Y human neuroblastoma cells, that is implicated in Parkinson's disease.
|
28883518 |
2017 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Calcipotriol inhibits α-synuclein aggregation in SH-SY5Y neuroblastoma cells by a Calbindin-D28k-dependent mechanism.
|
28164279 |
2017 |
|
Neuroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Neuroblastoma cells were stably transfected with wild type (WT) and A53T mutant alpha-synuclein.
|
16584840 |
2006 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, we concluded that α-synuclein inhibited the starvation-induced autophagy in neuroblastoma SH-SY5Y cells via inhibiting the mTOR/Atg 5 signaling.
|
29551576 |
2018 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We optimized an automated and reproducible assay to quantify both α-SYN aggregation and cell death in human SH-SY5Y neuroblastoma cells.
|
26620202 |
2016 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hence, in this study we analysed the influence of these two proteins (α-Syn and wild-type or mutant Atx3) on modified redox signaling, a pathological process potentially linked to both diseases, and also the impact of exposure to iron and rotenone in SH-SY5Y neuroblastoma cells.
|
28236214 |
2017 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we demonstrate that α-synuclein exists as defined, subcellular-specific species that change characteristics in response to oxidative stress in neuroblastoma cells and in response to Parkinson's disease pathogenesis in human cerebellum and frontal cortex.
|
27837450 |
2017 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The loss of viability in retinoic acid-differentiated SH-SY5Y human neuroblastoma cells inducibly overexpressing wild-type ASYN was associated with the reduced activation of AMPK and its activator LKB1, as well as AMPK target Raptor.
|
24269733 |
2014 |