Depressive disorder
|
0.200 |
Biomarker
|
disease |
BEFREE |
Results showed that the patients with lower α-synuclein presented more complaints on post-concussion symptoms and depression.
|
31040769 |
2019 |
Depressive disorder
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
<i>SNCA</i> mRNA expression was positively correlated with severity of depression as indicated by psychometric assessment.
|
31027150 |
2019 |
Depressive disorder
|
0.200 |
Biomarker
|
disease |
BEFREE |
A significantly higher α-synuclein burden was observed in the substantia nigra (P = 0.006), ventral tegmental area (P = 0.011) and nucleus accumbens (P = 0.031) in LBD patients with depression.
|
30582885 |
2019 |
Depressive disorder
|
0.200 |
Biomarker
|
disease |
BEFREE |
Lewy bodies inclusion and aggregation of α-Synuclein (α-Syn) during the pathogenesis of Parkinson's disease (PD) serve as a good example and are potentially linked to other pathological PD features such as progressive dopaminergic neuron cell death, behavioral defects, and nonmotor symptoms like anosmia, cognitive impairment, and depression.
|
30482039 |
2019 |
Depressive disorder
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Although in comparison to IPD, SNCA duplication carriers have the most similar course of disease, even for duplication carriers the frequencies of dementia, hallucinations, and depression seem higher than in IPD.
|
28802919 |
2017 |
Depressive disorder
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To investigate possible associations of Parkinson's disease (PD) with polymorphism in depression-related genes and in the alpha-synuclein (SNCA) gene.
|
28320136 |
2017 |
Depressive disorder
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Stepwise logistic regression model found that female sex, UPDRS part II score, motor fluctuation, GBA L1444P and SNCA Rep-1 variants collectively best predict depression in PD.
|
27745782 |
2016 |
Depressive disorder
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
This study demonstrates that AAV-mediated α-synuclein overexpression in dopamine neurons is not only useful to model motor impairments of PD, but also depression.
|
26363495 |
2015 |
Depressive disorder
|
0.200 |
Biomarker
|
disease |
BEFREE |
Parkinson's disease, neuropathologically defined by the aggregation of α-synuclein, is characterized by neuropsychiatric symptoms such as depression and anxiety preceding the onset of motor symptoms.
|
26201615 |
2015 |
Depressive disorder
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The associations of hyposmia with SNCA variants and disease phenotypic characteristics including motor symptoms (UPDRS motor score) and other common NMSs (clinical possible RBD-cpRBD, depression and chronic constipation) were analyzed.
|
25921825 |
2015 |
Depressive disorder
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The patients carrying the SNCA triplication developed early-onset parkinsonism combined with depression, behavior disturbances, sleep disorders, and cognitive decline; marked autonomic dysfunctions were not observed.
|
26077166 |
2015 |
Depressive disorder
|
0.200 |
Biomarker
|
disease |
BEFREE |
NACP-Rep1 relates to Beck Depression Inventory scores in healthy humans.
|
21271299 |
2011 |
Depressive disorder
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Alpha-synuclein mRNA levels correspond to beck depression inventory scores in females with eating disorders.
|
18799894 |
2008 |
Depressive disorder
|
0.200 |
Biomarker
|
disease |
HPO |
|
|
|