SNCA, synuclein alpha, 6622

N. diseases: 449; N. variants: 66
Disease: Iron Overload ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.030 Biomarker disease BEFREE Natural resistance-associated macrophage protein-1 (Nramp1) was previously shown to contribute to the degradation of extracellular α-synuclein in microglia under conditions of iron overload. 29679389 2019
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.030 Biomarker disease BEFREE Collectively, these findings suggest that the function of Nramp1 contributes to microglial degradation of oligomeric α-synuclein under iron overload condition and may be implicated in the pathogenesis of PD. 28476637 2017
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.030 GeneticVariation disease BEFREE We hence hypothesized that iron overload could selectively influence mutant alpha-synuclein toxicity and disease phenotypes. 26769358 2016