|
Squamous cell carcinoma of esophagus
|
0.100 |
Biomarker
|
disease |
BEFREE |
The regulatory relationship between ROR, miR-145 and FSCN1 was verified in ESCC cells via qRT-PCR, dual luciferase reporter (DLR) assay, RNA immunoprecipitation (RIP) and Western blotting.
|
29430188 |
2018 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, <i>lncRNA-TTN-AS1</i> also induces FSCN1 expression by sponging <i>miR-133b</i> and upregulation of mRNA-stabilizing protein HuR, which further promotes ESCC invasion cascades.
|
29101304 |
2018 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
Biomarker
|
disease |
BEFREE |
We identified 11 emerging IHC markers with reproducible results, including eight markers [epidermal growth factor receptor (EGFR), Cyclin D1, vascular endothelial growth factor (VEGF), Survivin, Podoplanin, Fascin, phosphorylated mammalian target of rapamycin (p-mTOR), and pyruvate kinase M2 (PKM2)] indicating unfavorable prognosis and 3 markers (P27, P16, and E-cadherin) indicating favorable prognosis of ESCC.
|
28818096 |
2017 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, serum level of autoantibodies against Fascin in early-stage ESCC was significantly higher than that of normal controls (P<0.05).
|
27956255 |
2017 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Network Analyses of Gene Expression following Fascin Knockdown in Esophageal Squamous Cell Carcinoma Cells.
|
26225692 |
2015 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
Biomarker
|
disease |
BEFREE |
FSCN1 and MMP14 were evaluated by immunohistochemistry and quantitative PCR, and microRNA (miR)-133a was also evaluated by PCR in surgical ESCC specimens.
|
24196787 |
2014 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Previously we conducted a microarray experiment to analyze fascin knockdown by RNAi in ESCC.
|
24460279 |
2013 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The protein level of FSCN1 showed no significant linear correlation with miR-143 and miR-145 expression in ESCC cell lines with Western blotting analysis.
|
22457808 |
2012 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fascin has a potential role as an early detection biomarker and CK4 as a tumor marker in ESCC.
|
21498718 |
2011 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
Biomarker
|
disease |
BEFREE |
This indicates that targeting fascin pathway could be a novel therapeutic strategy for the human ESCC.
|
20565981 |
2010 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Survival analysis showed that high expression of fascin was significantly associated with a poor prognosis of the patients with ESCC (p=0.004).
|
20713986 |
2010 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
Biomarker
|
disease |
BEFREE |
An FSCN1 loss-of-function assay found significant cell growth and invasion inhibition, implying an FSCN1 is associated with ESCC carcinogenesis.
|
21351259 |
2010 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Specificity protein 1 regulates fascin expression in esophageal squamous cell carcinoma as the result of the epidermal growth factor/extracellular signal-regulated kinase signaling pathway activation.
|
20502940 |
2010 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
Biomarker
|
disease |
BEFREE |
To confirm the immunohistochemical results, three proteins, fascin, CK14 and laminin-5gamma2, which were overexpressed in ESCC on tissue microarray, were detected in 12 ESCC cell lines by Western blot assay.
|
17187659 |
2006 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggested that fascin might play crucial roles in regulating neoplasm progression of ESCC.
|
16185662 |
2005 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
Biomarker
|
disease |
BEFREE |
The role of fascin in cell motility and invasiveness in ESCC cells was assessed by the vector-based small interfering RNA.
|
15814639 |
2005 |