SOD1, superoxide dismutase 1, 6647

N. diseases: 689; N. variants: 68
Disease: Cataract ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0086543
Disease: Cataract
Cataract 		0.040 AlteredExpression disease BEFREE CONCLUSIONS In HLECs, expression of miR-378a regulated ROS and PI3K/AKT signaling, and miR-378a was upregulated, and SOD1 was down-regulated in human cataract tissue. 31178586 2019
CUI: C0086543
Disease: Cataract
Cataract 		0.040 PosttranslationalModification disease BEFREE Both H3 and H4 were deacetylated at -600 bp of the SOD1 promoter of cataract lenses, and hypoacetylated at -1500, -1200, and -900 bp. 27703255 2016
CUI: C0086543
Disease: Cataract
Cataract 		0.040 GeneticVariation disease BEFREE If genetic variation in genes encoding SOD-1, SOD-2 and SOD-3 contributes to cataract formation, there is no major contribution of the SNPs analyzed in the present study. 23289810 2013
CUI: C0086543
Disease: Cataract
Cataract 		0.040 GeneticVariation disease BEFREE Stratification by the subtypes revealed that association between SOD polymorphism and cataract was in cortical and mixed type cataract. 21921984 2011