Amyotrophic Lateral Sclerosis With Dementia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Resveratrol treatment reduces the vulnerability of SH-SY5Y cells and cortical neurons overexpressing SOD1-G93A to Thimerosal toxicity through SIRT1/DREAM/PDYN pathway.
|
30503815 |
2019 |
Amyotrophic Lateral Sclerosis With Dementia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Lack of synergistic effect of resveratrol and sigma-1 receptor agonist (PRE-084) in SOD1G⁹³A ALS mice: overlapping effects or limited therapeutic opportunity?
|
24885036 |
2014 |
Amyotrophic Lateral Sclerosis With Dementia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Identification of a misfolded region in superoxide dismutase 1 that is exposed in amyotrophic lateral sclerosis.
|
25164820 |
2014 |
Amyotrophic Lateral Sclerosis With Dementia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Motor neuron dysfunction in a mouse model of ALS: gender-dependent effect of P2X7 antagonism.
|
23583883 |
2013 |
Amyotrophic Lateral Sclerosis With Dementia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Bromocriptine methylate suppresses glial inflammation and moderates disease progression in a mouse model of amyotrophic lateral sclerosis.
|
21867702 |
2011 |
Amyotrophic Lateral Sclerosis With Dementia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Mutant SOD1 knockdown in all cell types ameliorates disease in G85R SOD1 mice with a limited additional effect over knockdown restricted to motor neurons.
|
20132483 |
2010 |
Amyotrophic Lateral Sclerosis With Dementia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Disrupted zinc-binding sites in structures of pathogenic SOD1 variants D124V and H80R.
|
20515040 |
2010 |
Amyotrophic Lateral Sclerosis With Dementia
|
0.300 |
Biomarker
|
disease |
CTD_human |
From transcriptome analysis to therapeutic anti-CD40L treatment in the SOD1 model of amyotrophic lateral sclerosis.
|
20348957 |
2010 |
Amyotrophic Lateral Sclerosis With Dementia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Rapid one-step purification of native dimeric ALS-associated human Cu/Zn superoxide dismutase from transgenic rat tissues.
|
19929749 |
2010 |
Amyotrophic Lateral Sclerosis With Dementia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Transcriptional profiling in the lumbar spinal cord of a mouse model of amyotrophic lateral sclerosis: a role for wild-type superoxide dismutase 1 in sporadic disease?
|
20177826 |
2010 |
Amyotrophic Lateral Sclerosis With Dementia
|
0.300 |
Biomarker
|
disease |
CTD_human |
A common property of amyotrophic lateral sclerosis-associated variants: destabilization of the copper/zinc superoxide dismutase electrostatic loop.
|
19635794 |
2009 |
Amyotrophic Lateral Sclerosis With Dementia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Superoxide dismutase 1 mutants related to amyotrophic lateral sclerosis induce endoplasmic stress in neuro2a cells.
|
18233996 |
2008 |
Amyotrophic Lateral Sclerosis With Dementia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis.
|
17496168 |
2007 |
Amyotrophic Lateral Sclerosis With Dementia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Protein-bound crotonaldehyde accumulates in the spinal cord of superoxide dismutase-1 mutation-associated familial amyotrophic lateral sclerosis and its transgenic mouse model.
|
17319283 |
2007 |
Amyotrophic Lateral Sclerosis With Dementia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Metallothionein proteins expression, copper and zinc concentrations, and lipid peroxidation level in a rodent model for amyotrophic lateral sclerosis.
|
17097207 |
2007 |
Amyotrophic Lateral Sclerosis With Dementia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Familial amyotrophic lateral sclerosis with frontotemporal dementia is linked to a locus on chromosome 9p13.2-21.3.
|
16495328 |
2006 |
Amyotrophic Lateral Sclerosis With Dementia
|
0.300 |
Biomarker
|
disease |
CTD_human |
A therapeutic role for cyclooxygenase-2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis.
|
12586733 |
2003 |
Amyotrophic Lateral Sclerosis With Dementia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Glycation proceeds faster in mutated Cu, Zn-superoxide dismutases related to familial amyotrophic lateral sclerosis.
|
12626432 |
2003 |
Amyotrophic Lateral Sclerosis With Dementia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Increased expression of the pro-inflammatory enzyme cyclooxygenase-2 in amyotrophic lateral sclerosis.
|
11220737 |
2001 |
Amyotrophic Lateral Sclerosis With Dementia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Oxidative stress causes abnormal accumulation of familial amyotrophic lateral sclerosis-related mutant SOD1 in transgenic Caenorhabditis elegans.
|
11590119 |
2001 |
Amyotrophic Lateral Sclerosis With Dementia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Transgenic SOD1 G93A mice develop reduced GLT-1 in spinal cord without alterations in cerebrospinal fluid glutamate levels.
|
11723166 |
2001 |
Amyotrophic Lateral Sclerosis With Dementia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Increased reactive oxygen species in familial amyotrophic lateral sclerosis with mutations in SOD1.
|
10930589 |
2000 |
Amyotrophic Lateral Sclerosis With Dementia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Renal tubular impairment during riluzole therapy.
|
10025816 |
1999 |
Amyotrophic Lateral Sclerosis With Dementia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Clinical and functional investigation of 10 missense mutations and a novel frameshift insertion mutation of the gene for copper-zinc superoxide dismutase in UK families with amyotrophic lateral sclerosis.
|
9065559 |
1997 |
Amyotrophic Lateral Sclerosis With Dementia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Identification of new mutations in the Cu/Zn superoxide dismutase gene of patients with familial amyotrophic lateral sclerosis.
|
7887412 |
1995 |