SORL1, sortilin related receptor 1, 6653

N. diseases: 103; N. variants: 29
Disease: Senile Plaques ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0333463
Disease: Senile Plaques
Senile Plaques 		0.020 Biomarker disease BEFREE Proteins encoded by SORL1 and ACE have been shown to be related to the processing, trafficking, and degradation of Amyloid-β, the principal component of senile plaques. 20625269 2015
CUI: C0333463
Disease: Senile Plaques
Senile Plaques 		0.020 Biomarker disease BEFREE The sortilin-related receptor SorLA/LR11 (LR11) is a transmembrane neuronal sorting protein that reduces beta-amyloid precursor protein trafficking to secretases, notably BACE1 that generates beta-amyloid, the principal component of senile plaques in Alzheimer disease (AD). 19364929 2009