Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results demonstrated that the glioma neurosphere cells positively expressed stem cell marker SOX2, neuroectodermal stem cell marker Nestin, and also expressed astrocytes marker GFAP and neurons marker β-tubulin III fter FBS-induced differentiation for a week, which proved the glioma neurosphere cells have the self-renewal and multipotential differentiation capacity.
|
28592121 |
2019 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Both forced SOX2 expression and OPA1 inactivation increased LN319 glioma cell invasion in vitro and promoted cell dispersion in vivo in xenotransplanted D. rerio embryos.
|
30403311 |
2019 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Targeting of replicating CD133 and OCT4/SOX2 expressing glioma stem cells selects a cell population that reinitiates tumors upon release of therapeutic pressure.
|
31267022 |
2019 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Author Correction: Invasion of white matter tracts by glioma stem cells is regulated by a NOTCH1-SOX2 positive-feedback loop.
|
30903095 |
2019 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Altogether, these findings highlight the role of FHL3 as a stemness-suppressor in regulation of the Smad2/3-SOX4-SOX2 axis in glioma.
|
29955125 |
2019 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
For cases with SOX2 high expression in the primary glioma, those had SOX2 low expression after recurrence seemed to have worse prognosis as compared to patients with stable SOX2 high expression (PFS: 10.4 vs. 14.9 months, p = 0.036; OS: 27.0 vs 49.5 months, p = 0.005).
|
31718604 |
2019 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Invasion of white matter tracts by glioma stem cells is regulated by a NOTCH1-SOX2 positive-feedback loop.
|
30559479 |
2019 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MALAT1 enhanced glioma stem cell viability and proliferation abilities and promoted glioma tumorigenesis through suppressing miR-129 and facilitating SOX2 expressions.
|
29808528 |
2018 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
NEAT1 negatively regulated the expression of miR-132 in glioma while miR-132 targeted SOX2 to down-regulate its expression.
|
30053878 |
2018 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Genetic probes showed that mouse GBM-derived CTC exhibited Sox2/ETn transcriptional activation and expressed glioma CSC markers, consistent with robust expression of stemness-associated genes including SOX2, OCT4, and NANOG in human GBM patient-derived samples containing CTC.
|
30322863 |
2018 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
NOS2 expression in glioma cell lines and glioma primary cell cultures: correlation with neurosphere generation and SOX-2 expression.
|
28424427 |
2017 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The Expression of Connexins and SOX2 Reflects the Plasticity of Glioma Stem-Like Cells.
|
28654819 |
2017 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
<i>Sox2-V5</i> and <i>Sox2-mCherry</i>); and (4) engineering of glioma mutations (<i>TP53</i> deletion; <i>H3F3A</i> point mutations).
|
28096221 |
2017 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Sox2 overexpression also promoted glioma cell migration and invasion, whereas Sox2 siRNA markedly reduced the miR‑21‑enhanced migration and invasion of glioma cells, indicating Sox2 may act as a crucial mediator of miR‑21 function.
|
27909726 |
2017 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The presence of T-cell immunity to SOX2 was examined in both blood and tumor-infiltrating T-cells in children and young adults with glioma.
|
28620836 |
2017 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry and flow cytometry analysis of 12 tumor samples obtained from patients with high grade gliomas revealed that a considerable population (2-19%) of cells in all malignant gliomas expressed IL-17RA, with remarkable co-expression of the glioma stem cell (GSC) markers CD133, Nestin, and Sox2.
|
26755664 |
2016 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Together, this is the first study to show that the inhibition of Bcl11b suppresses glioma cell growth by regulating the expression of the cell cycle regulator p21 and stemness-associated genes (Sox-2/Bmi-1).
|
26096706 |
2016 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Accumulating evidence shows that SOX2 is overexpressed in several human tumors, including lung cancer, esophageal carcinoma, pancreatic carcinoma, breast cancer, ovarian carcinoma and glioma.
|
26001828 |
2015 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In a spontaneous mouse model of glioma, ectopic expression of the IE1 gene (UL123) specifically increased Sox2 and Nestin levels in the IE1-positive tumors, upregulating stemness and proliferation markers in vivo.
|
26239477 |
2015 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our RCAS-tva/Sox2-EGFP model will empower closer examination of cellular heterogeneity and will be useful for identifying novel glioma pathways as well as testing preclinical treatment efficacy.
|
25416826 |
2015 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, we concluded that the G9a-dependent H3K9me2 repression on CD133 and Sox2 was one of the main switches of the self-renewal in glioma cancer stem cells.
|
24833465 |
2014 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Upon irreversible depletion of miR-21 the expression of SOX2 was strongly diminished in both mouse primary glioma cultures and human glioma cell lines.
|
22931209 |
2012 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
And, the ectopic expression of Sox2 attenuated the apoptotic effect of As(2)O(3) on glioma cell.
|
21703238 |
2011 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The glioma stem cells obtained from CD133+ cells demonstrated increased expression of Twist1 and Sox2 accompanied by significant increase in the mesenchymal markers such as N-cadherin, vimentin and β-catenin.
|
22184289 |
2011 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
SOX2 expression and amplification in gliomas and glioma cell lines.
|
21518820 |
2011 |