|
Squamous cell carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
SOX2 amplification is one of the most common genetic alterations in SCC.
|
30838525 |
2019 |
|
Squamous cell carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Dysregulated Tgfbr2/ERK-Smad4/SOX2 Signaling Promotes Lung Squamous Cell Carcinoma Formation.
|
31209059 |
2019 |
|
Squamous cell carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, by investigating the super-enhancer landscape of LUSC, we identified a previously undescribed "neural" subtype defined by Sox2 and a neural lineage factor Brn2, as well as the classical LUSC subtype defined by Sox2 and its classical squamous partner p63.
|
31551362 |
2019 |
|
Squamous cell carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
As an example, high SOX2 expression in lung squamous cell carcinoma (SCC) is related to a favorable prognosis, while it is associated with poor outcome in lung adenocarcinoma.
|
29596469 |
2018 |
|
Squamous cell carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent studies have found a large number of DNA alterations such as SOX2 amplification in LSCC patients.
|
29854282 |
2018 |
|
Squamous cell carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
LUAD A549 cells and LUSC H520 cells were used to investigate the influence of SPC25 on cancer stem cell (CSC) properties in terms of the proportion of CD133<sup>+</sup> cells, tumorsphere formation and CSC markers, including CD133, ALDH1 and Sox2.
|
29432994 |
2018 |
|
Squamous cell carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.
|
28794006 |
2017 |
|
Squamous cell carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The lncRNA SOX2-OT, a common driver of HNSC and LUSC, showed significant expression correlation with the oncogene SOX2.
|
28719033 |
2017 |
|
Squamous cell carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The lung SCC cell line also showed higher levels of SOX2 and cyclin D1 expression than a normal human bronchial epithelium cell line.
|
28151013 |
2017 |
|
Squamous cell carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
We assessed the expressions of Gli1, LSD1, CD44, Sox9 and Sox2 by immunohistochemistry in the tissue specimens obtained from 101 patients with LSCC.
|
28286162 |
2017 |
|
Squamous cell carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
SOX2 suppresses CDKN1A to sustain growth of lung squamous cell carcinoma.
|
26846300 |
2016 |
|
Squamous cell carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interestingly, Sox2;Pten;Cdkn2ab mice develop LSCC with a more peripheral location when Club or Alveolar type 2 (AT2) cells are targeted.
|
27728803 |
2016 |
|
Squamous cell carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our data suggested that SOX2 overexpression could be used as a positive prognostic factor in patients with stage III lung SCC receiving adjuvant radiotherapy.
|
26323639 |
2016 |
|
Squamous cell carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
We identified networks regulated by known cancer drivers such as GATA3 and FOXA1 (breast cancer), SOX17 and FOXA2 (endometrial cancer), and NFE2L2, SOX2, and TP63 (squamous cell lung cancer).
|
25994056 |
2015 |
|
Squamous cell carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of the present study was to evaluate FGFR1, PIK3CA and SOX2 protein expression in SQCC and determine whether the expression of these can be used as prognostic biomarkers.
|
25384882 |
2015 |
|
Squamous cell carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sox2 cooperates with Lkb1 loss in a mouse model of squamous cell lung cancer.
|
24953650 |
2014 |
|
Squamous cell carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we show that BMP4 is a downstream target of SOX2 in lung SQC.
|
24477565 |
2014 |
|
Squamous cell carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
The PRKCI and SOX2 oncogenes are coamplified and cooperate to activate Hedgehog signaling in lung squamous cell carcinoma.
|
24525231 |
2014 |
|
Squamous cell carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The arsenic-related tumor exhibited alterations common in LUSC, such as the increased number of copies at 3q26 (SOX2 locus).
|
24128716 |
2013 |
|
Squamous cell carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
SOX2 gene amplification and protein overexpression are associated with better outcome in squamous cell lung cancer.
|
21460799 |
2011 |