Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In vivo experiments using surgically-induced OA rats showed <sub>MC</sub> SOX9/6/shANG-tADSC-treated rats had significantly lower levels of cyclooxygenase (COX-2) and MMP13 in synovial fluids than <sub>MC</sub> SOX9/6-tADSC-treated rats, but no significant difference was observed between them in histological appearances.
|
30957437 |
2020 |
Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human chondrocyte cell lines, CHON-001 and ATDC5, were treated with different doses of interleukin-1β (IL-1β) to simulate the inflammatory response environment of OA. miR-138-5p mimics, miR-138-5p inhibitors and SOX9 small interfering RNA (siRNA) were constructed and transfected into CHON-001 and ATDC5 cells.
|
31486753 |
2020 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
When locally administered in vivo in an OA mouse model, the hydrogels demonstrated the ability to restore, to some extent, bone remineralization, proteoglycan production, levels of Sox-9 and Runx-2.
|
30968404 |
2019 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
While H-PRP showed similar effects on expression of chondrogenic markers (Col2a1 and Sox9) as the negative control group (p > 0.05), OA-PRP decreased chondrocyte expression of Col2a1 and Sox-9 messenger RNA by 40% and 30%, respectively (Col2a1, p = 0.015; Sox9, p = 0.037).
|
31042308 |
2019 |
Degenerative polyarthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Moreover, the G allele of the polymorphism rs12601701 and the A allele of the polymorphism rs1042667 could significantly elevate the risk of OA (OR = 2.075, 95%CI = 1.021-4.218).SOX9 polymorphism rs1042667 may be a risk factor for OA in Chinese Han population.
|
30813126 |
2019 |
Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In vivo, the effect of SOX9 on surgically induced OA mice was evaluated.
|
31496660 |
2019 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Both peptides, however, reversed the downregulation of SOX9 and aggrecan (ACAN), and decrease of COL10A1 gene expression in preserved human OA cartilage explants.
|
29559252 |
2018 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This study aimed to determine the collagen type II (COL2) and SOX9 expression in interleukin growth factor (IGF-1)-induced Wharton's Jelly mesenchymal stem cells (WJMSCs) and the level of chondrogenic markers in co-culture IGF1-WJMSCs and IL1β-CHON002 as osteoarthritis (OA) cells model.
|
30140415 |
2018 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
There was a significant reduction in miR-140 and SOX9 expression in OA groups compared to the normal group, and there was a further reduction in the severe OA group compared to the moderate OA group.
|
29753378 |
2018 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PSMD11 gain-of- function by transfection increased proteasomal function, increased levels of SOX9-induced AGC1 mRNA, stimulated elements of the autophagic machinery, and inhibited extracellular levels of interleukin-1-induced NO and matrix metalloproteinase 13 in OA chondrocytes.
|
29457374 |
2018 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results indicated that OA mice exhibited decreased expression of SOX9 and NF-kB but higher miR-384-5p expression.
|
30057417 |
2018 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In particular, SOX9 and ACAN gene expression and GAG synthesis were more abundant in hADSCs than hBMSCs when cultured in OSF.
|
27739057 |
2017 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, cells from the mild OA subjects showed significantly higher levels of CD105, Sox9 and Acan compared with those from severe OA specimens.
|
28805694 |
2017 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Cartilage degeneration in OA is a gradual progress accompanied with gradual loss of collagen type II and a gradual decrease in mRNA expression of SOX9, ACAN and COL2A1.
|
27428952 |
2016 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, increased SOX9 and CD90 as well as reduced CD166 expression levels in OA-BMSCs warrant further investigation.
|
27155399 |
2016 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
miR-30a was significantly upregulated and Sox9 was downregulated in primary chondrocytes from cartilage taken from OA donors compared to healthy controls.
|
26969024 |
2016 |
Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, SOX9 could be used as a potential therapeutic agent for human OA at an early stage.
|
26162802 |
2015 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These findings indicate that OA is a disease associated with immune system activation and decreased expression of SOX-9 gene in OA menisci.
|
25525593 |
2014 |
Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
There was a significant increase in H3K9 and H3K27 trimethylation and a significant decrease in the acetylation of H3K9, 15, 18, 23, and 27 at SOX-9 promoters in OA chondrocytes.
|
23225119 |
2013 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, we conclude that co-expression of the α2M and Sox9 genes, combined with chitosan‑mediated gene delivery, will offer potential as a novel means by which to treat OA via intra-articular injection.
|
22484373 |
2012 |
Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We confirmed that SOX9 is an ERRα target gene in human, as in rodent, chondrocytes and identified MMP-13 as a potential new target gene, which suggests that ERRα may both respond to the healing signal and contribute to extracellular degradation in OA cartilage.
|
21506092 |
2011 |
Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
SOX-5, SOX-6, and SOX-9 gene expressions significantly decreased by 41% (p = 0.047), 46% (p = 0.047), and 56% (p = 0.029) in advanced OA area compared with the minimally OA area.
|
21728837 |
2011 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
SOX9 (38-fold) and aggrecan (4-fold) gene expression were both lower in OA (p<0.001), and collagen I (17-fold) and II (2.5-fold) gene expression were each increased in a subset of OA samples.
|
19103633 |
2010 |
Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The expression of 661 genes, including COMP, FN1, and SOX9, was differentially regulated between OA and ND chondrocytes cultured in monolayer.
|
19723327 |
2009 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
SOX9 transcript levels were substantially reduced in osteoarthritis.
|
18550917 |
2008 |