|
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
NR2F1-AS1 regulated miR-423-5p/SOX12 to promote proliferation and invasion of papillary thyroid carcinoma.
|
31692033 |
2020 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, SOX12 is a novel prognostic biomarker and regulator of GC metastasis.
|
30922917 |
2019 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Administration of L-asparaginase decreased SOX12-mediated tumor growth and metastasis.
|
30858360 |
2019 |
|
Tumor Cell Invasion
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
Overexpression of SOX12 partially rescued the inhibitory effect on cell proliferation, migration and invasion in breast cancer cells caused by miR-326 overexpression.
|
31311830 |
2019 |
|
Tumor Cell Invasion
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
Notably, overexpression of SOX12 antagonized the suppressive effect of miR‑744 on HCC cell migration and invasion.
|
30542724 |
2018 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
The Sox12+ cells were compared with Sox12- HCC cells for tumor sphere formation, chemo-resistance, tumor formation after serial adoptive transplantations in nude mice, and the frequency of developing distal metastasis.
|
29127951 |
2017 |
|
Neoplasm Metastasis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
CDK4 and IGF2BP1 were among the top 20 SOX12 co-upregulated genes in HCC, which have well characterized enhancing the effect on HCC cell growth, invasion, and metastasis.
|
28975985 |
2017 |
|
Neoplasm Metastasis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
Knockdown of SOX12 expression inhibits the proliferation and metastasis of lung cancer cells.
|
28979676 |
2017 |
|
Tumor Cell Invasion
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
In this study, we studied the expression profile of SOX12 gene in different pathological stages of hepatocellular carcinoma (HCC) and explored the possible downstream genes related to its regulation of HCC invasion and migration.
|
28975985 |
2017 |
|
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Finally, the mRNA and protein levels of cell growth (PCNA and Cyclin E), apoptosis (Bcl-2 and Bax), invasion (matrix metalloproteinase-9) and epithelial-mesenchymal transition (EMT; Twist1 and E-cadherin) related moderators were affected by SOX12 knockdown.
|
28979676 |
2017 |
|
Liver carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Notably, overexpression of SOX12 antagonized the suppressive effect of miR‑744 on HCC cell migration and invasion.
|
30542724 |
2018 |
|
Liver carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Sex determining region Y-box protein 12 (SOX12) plays an important role in the tumorigenesis of hepatocellular carcinoma.
|
28979676 |
2017 |
|
Liver carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Thus, we conclude that Sox12 may be a novel marker for enriching CSCs in HCC.
|
29127951 |
2017 |
|
Liver carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
CDK4 and IGF2BP1 were among the top 20 SOX12 co-upregulated genes in HCC, which have well characterized enhancing the effect on HCC cell growth, invasion, and metastasis.
|
28975985 |
2017 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Administration of L-asparaginase decreased SOX12-mediated tumor growth and metastasis.
|
30858360 |
2019 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
<i>In vivo</i> tumorigenesis experiments showed that inhibition of SOX12 expression significantly suppressed the growth of xenograft tumors.
|
28979676 |
2017 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
The Sox12+ cells were compared with Sox12- HCC cells for tumor sphere formation, chemo-resistance, tumor formation after serial adoptive transplantations in nude mice, and the frequency of developing distal metastasis.
|
29127951 |
2017 |
|
Mantle cell lymphoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Here we report the variable expression of SOX4 and high expression of SOX12 in MCL compared to non-malignant tissue.
|
23466598 |
2013 |
|
Mantle cell lymphoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In this study we found variable expression of SOX11, SOX4 and SOX12 mRNA in mantle cell lymphoma cell lines.
|
21124928 |
2010 |
|
Papillary thyroid carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Consequently, we found that NR2F1-AS1 and SOX12 levels were elevated in PTC, whereas miR-423-5p was downregulated in PTC cells.
|
31692033 |
2020 |
|
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings suggested that miR-326 might play a suppressive role in breast cancer, at least in part, by targeting SOX12, rendering miR-326 a promising therapeutic target for breast cancer.
|
31311830 |
2019 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Downregulation of GLS, GOT2, and ASNS blocked SOX12-mediated CRC cell proliferation and metastasis, whereas ectopic expression of GLS, GOT2, and ASNS attenuated the SOX12 knockdown-induced suppression of CRC progression.
|
30858360 |
2019 |
|
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, SOX12 is a novel prognostic biomarker and regulator of GC metastasis.
|
30922917 |
2019 |
|
Pancreatic carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
MiR-29b suppresses proliferation and mobility by targeting SOX12 and DNMT3b in pancreatic cancer.
|
30601190 |
2019 |
|
Malignant neoplasm of pancreas
|
0.010 |
Biomarker
|
disease |
BEFREE |
MiR-29b suppresses proliferation and mobility by targeting SOX12 and DNMT3b in pancreatic cancer.
|
30601190 |
2019 |