|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
By advanced ultramicroscopy for studying single-cell invasion in whole, undissected mouse brains, we show that gliomas require SPARC for invading into white matter structures.
|
31062076 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
SPARC enhances HSA accumulation in U87MG glioma and mediates active targeting of HSA in tumors.
|
31695779 |
2019 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We demonstrated that the albumin nanoparticles modified with dual ligands, a transferrin receptor (TfR)-binding peptide T12 and mannose, efficiently passed through the BBB <i>via</i> the nutrient transporters (<i>i.e.</i>, TfR and the albumin-binding receptor SPARC) that were both overexpressed in the BBB and glioma cells, thus achieving biomimetic delivery to glioma.
|
29732051 |
2018 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results indicate that the loss of p53 by deletion/mutation in the early stages of glioma formation may cooperate with the induction of SPARC to potentiate cancer cell survival and escape from immune surveillance.
|
24862407 |
2015 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We previously demonstrated that SPARC promotes glioma migration and invasion-in part, by activating the P38 mitogen-activated protein kinase (MAPK)-heat shock protein (HSP)27 signaling pathway.
|
23382286 |
2013 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
GFP, SPARC-GFP and the two deletion mutants were expressed in U87MG glioma cells.
|
22114076 |
2012 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We conclude that inhibition of HSP27 alone, or in combination with pAKT inhibitor IV, may be an effective therapeutic approach to inhibit SPARC-induced glioma cell invasion and survival in SPARC-positive/PTEN-wildtype and SPARC-positive/PTEN-null tumors, respectively.
|
22480225 |
2012 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Hence, our data demonstrate that IRE1α is a key regulator of SPARC expression in vitro in a glioma model.
|
22718352 |
2012 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, we investigated the effects of downregulated SPARC expression on the radiosensitivity of human glioma U-87MG cells and its possible mechanism.
|
22145659 |
2011 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, intracerebral injection of glioma cells transfected with SPARC siRNA in nude mice resulted in the formation of a non-invasive tumor, whereas injection of cells transfected with control siRNA resulted in diffuse invasive tumors.
|
19212676 |
2009 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To further our understanding regarding SPARC function in glioma migration, we transfected SPARC-green fluorescent protein (GFP) and control GFP vectors into U87MG cells, and assessed the effects of SPARC on cell morphology, migration, and invasion after 24 h. The expression of SPARC was associated with elongated cell morphology, and increased migration and invasion.
|
18442089 |
2008 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Secreted protein acidic and rich in cysteine (SPARC) is highly expressed in human gliomas and promotes glioma invasion.
|
17490812 |
2007 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
These data further demonstrate the role of SPARC in glioma tumor progression through the activation of intracellular kinases that may provide novel therapeutic targets for advanced cancers.
|
17213807 |
2007 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Secreted protein acidic, rich in cysteine (SPARC), mediates cellular survival of gliomas through AKT activation.
|
15469933 |
2004 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further investigation of these candidates may shed insights into SPARC's role in glioma cell proliferation and invasion, and potential use as a therapeutic target.
|
12510773 |
2002 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
LHGDN |
These data suggest that SPARC may modulate glioma proliferation and invasion by modulating both the growth and migration of glioma cells.
|
11716067 |
2001 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data suggest that SPARC may modulate glioma proliferation and invasion by modulating both the growth and migration of glioma cells.
|
11716067 |
2001 |