Disease: Systemic Scleroderma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.060 AlteredExpression disease BEFREE Extracellular SPARC cooperates with TGF-β signalling to induce pro-fibrotic activation of systemic sclerosis patient dermal fibroblasts. 31840182 2019
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.060 Biomarker disease BEFREE Attenuation of collagen production with small interfering RNA of SPARC in cultured fibroblasts from the skin of patients with scleroderma. 16871529 2006
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.060 GeneticVariation disease BEFREE Single-nucleotide polymorphisms (SNPs) in the SPARC gene are reportedly linked to scleroderma in four ethnic groups: Choctaw Indians, Caucasians, African Americans and Mexican Americans. 15546965 2005
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.060 GeneticVariation disease BEFREE Moreover, a genetic polymorphism in SPARC has been associated with susceptibility to scleroderma. 15641096 2005
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.060 GeneticVariation disease BEFREE Five polymorphic microsatellite markers within 5 cM of the SPARC gene (chromosome 5q31-32) were genotyped in Choctaw Indians, a population previously shown to have a high prevalence of SSc. 12428242 2002
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.060 Biomarker disease BEFREE The apparent overproduction of osteonectin by scleroderma fibroblasts is in accordance with the suggested activation of osteonectin expression during tissue remodeling. 2023219 1991