Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
OPN is the major phosphoprotein secreted by malignant cells in patients with advanced metastatic cancer, is frequently overexpressed in human tumors, and has been implicated as a key mediator of tumor cell metastasis.
|
16047475 |
2005 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
OPN has been linked with tumor metastasis and signifies a poor prognosis for the patient.
|
18508515 |
2008 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Osteopontin (OPN), a secreted phosphoglycoprotein, is frequently associated with cell proliferation and tumor metastatic spread in a variety of cancers.
|
20207476 |
2010 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Osteopontin (OPN) is a variably expressed, secreted glycophosphoprotein that mediates the growth and metastases of hepatocellular cancer (HCC).
|
20576283 |
2010 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Osteopontin (OPN) is a variably expressed, secreted glycophosphoprotein that mediates the growth and metastases of several carcinoma types.
|
21207061 |
2011 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
OPN is associated with tumor metastasis of several tumors and is overexpressed in hepatocellular carcinoma (HCC) tissue involving HCC invasion and metastasis.
|
24240095 |
2013 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Osteopontin is related to tumor metastasis and proliferation.
|
25725928 |
2015 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Osteopontin (OPN) is an Extracellular Matrix (ECM) molecule and is involved in many physiologic and pathologic processes, including cell adhesion, angiogenesis and tumor metastasis.
|
26509489 |
2015 |
Secondary Neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
As shown by real-time PCR analysis, melanoma metastases that were homozygous for the -443C allele expressed significantly higher levels of OPN mRNA compared with those that were either heterozygous (-443T/C) or homozygous for the -443T allele.
|
18459127 |
2009 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Collectively, our results indicate that the OPN-CCR1 axis in HCC is important for accelerating tumor metastasis and that CCR1 is a potential therapeutic target for controlling metastasis in HCC patients with high OPN.
|
29285854 |
2018 |
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Following transfection of Rama 37 cells with an expression-construct producing elevated levels of OPN, the newly-transfected cells, when introduced into the rat host, developed metastases in 55% of the animals that produced primary tumours.
|
8700559 |
1996 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Further study demonstrated that VEGF/OPN-BsAb could effectively suppress primary tumor growth and metastasis to lungs, suggesting that it might be a promising therapeutic agent for treatment of metastatic cancer.
|
20826049 |
2010 |
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, high levels of OPN were detected in vesicles derived from rats harboring breast cancer skeletal metastases.
|
31590218 |
2019 |
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Here we report that TIP30 suppresses metastasis of hepatocellular carcinoma (HCC) through inhibiting the transcription of osteopontin (OPN), a key molecule in the development of tumor metastasis.
|
18537194 |
2008 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
However, the mechanisms by which OPN promotes tumor metastasis remain unclear.
|
21286666 |
2011 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
However, the molecular mechanisms that define the role of OPN in tumor metastasis are incompletely understood.
|
15501463 |
2004 |
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Importantly, JNK inhibition or disruption of SPP1 or TNC expression sensitizes experimental mammary tumors and metastases to chemotherapy, thus providing insights to consider for future treatment strategies against metastatic breast cancer.
|
30190333 |
2018 |
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In addition, DLC1 down-regulated the expression of osteopontin and matrix metalloproteinase-9, which are highly up-regulated in most primary HCC with associated metastases.
|
18497990 |
2008 |
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In conclusion, Expression of OPN in the tissue of HCC is related to metastasis or metastases.
|
21188534 |
2011 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
In SW480 human colon cancer cells, we conclude that Sp1 mediated expression of the tumor metastasis protein, OPN, regulates in vitro functional correlates of tumor metastasis.
|
17689681 |
2007 |
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Increased accumulation of the targeted NPs was achieved in the primary mammary tumor of mice xenografted with MDA-MB-231 mammary carcinoma cells as well as in the lungs, one of the main sites affected by metastases. siOPN NPs treatment resulted in significant inhibition of tumor growth (similar bioactivity of both formulations), accompanied with significant reduction of OPN mRNA levels (~40% knockdown of mRNA levels).
|
30934857 |
2019 |
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
It may be noted that despite being a strong marker to identify human tumor metastasis, no study on effect of artemisinin and its synthetic and semisynthetic derivatives on OPN expression has ever been studied.
|
31791643 |
2020 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Suppression of OPN may be one of the possible underlying mechanisms of BRMS1-dependent suppression of tumor metastasis.
|
17227585 |
2007 |
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Taken together, these data suggest that OPN is an ERG-target gene in PCa where the abnormal expression of the transcription factor ERG, due to the TMPRSS2:ERG fusion, disturbs the expression of genes that play an important role in PCa cells and associated metastases.
|
21669963 |
2011 |
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The consistency of OPN transcriptional control between primary CRC and metastases is unclear.
|
21343932 |
2011 |