SPP1, secreted phosphoprotein 1, 6696

N. diseases: 824; N. variants: 13
Disease: Patent ductus arteriosus ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0013274
Disease: Patent ductus arteriosus
Patent ductus arteriosus 		0.060 Biomarker disease BEFREE Thus, the GLI2-OPN circuit is a driver of PDA cell plasticity that establishes and maintains an aggressive variant of this disease. 31134896 2019
CUI: C0013274
Disease: Patent ductus arteriosus
Patent ductus arteriosus 		0.060 AlteredExpression disease BEFREE Our aim was to examine the expression pattern of OPN splice variants a, b, and c in fine-needle aspirates and to determine their correlation with stage-adjusted pancreatic ductal adenocarcinoma (PDA) survival. 24548099 2014
CUI: C0013274
Disease: Patent ductus arteriosus
Patent ductus arteriosus 		0.060 AlteredExpression disease BEFREE OPNc and total OPN levels were correlated in the tissue from patients with invasive PDA. 21630219 2011
CUI: C0013274
Disease: Patent ductus arteriosus
Patent ductus arteriosus 		0.060 AlteredExpression disease BEFREE In this study, we explored the potential proinflammatory role of nicotine in PDA through studying its effect on the expression of monocyte chemoattractant protein (MCP)-1 and evaluated the role of OPN in mediating these effects. 20579680 2010
CUI: C0013274
Disease: Patent ductus arteriosus
Patent ductus arteriosus 		0.060 Biomarker disease BEFREE Here, we investigated the potential molecular basis of nicotine's role in PDA through studying its effect on OPN. 19358273 2009
CUI: C0013274
Disease: Patent ductus arteriosus
Patent ductus arteriosus 		0.060 AlteredExpression disease BEFREE The levels of OPNc correlated well with higher expression levels of total OPN in the tissue and serum from patients with invasive PDA. 19628079 2009