SPP1, secreted phosphoprotein 1, 6696
N. diseases: 824; N. variants: 13
Source: ALL
| Disease | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year |
|---|---|---|---|---|---|---|---|
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0.060 | GeneticVariation | disease | BEFREE | Helicobacter pylori infected patients (100 with and 210 without IM) were recruited to evaluate the associations of SPP1 promoter polymorphisms with gastric IM and adjusted for age, sex and smoking. | 28685609 | 2017 |
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0.060 | Biomarker | disease | BEFREE | The area under ROC from three-dimensional combination of PGI/II-HpAb-OPN (0.826) was significantly higher than two-dimensional combination of PGI/II-HpAb (0.786, P < 0.001), PGI/II-OPN (0.787, P < 0.001), and OPN-HpAb (0.801, P = 0.006), as well as one-biomarker of PGI/II (0.735, P < 0.001), HpAb (0.737, P < 0.001) and OPN(0.713, P < 0.001), respectively. | 28912586 | 2017 |
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0.060 | Biomarker | disease | BEFREE | Taken together, these results indicate that OPN exerts a considerable influence on HP-induced gastritis by modulating the production of cytokines and contributing to macrophage infiltration. | 25867766 | 2015 |
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0.060 | Biomarker | disease | BEFREE | In the present study, we investigated the pathogenic roles of OPN in Helicobacter pylori-induced gastric cancer development. | 26438603 | 2015 |
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0.060 | AlteredExpression | disease | BEFREE | The levels of serum OPN and serum Helicobacter pylori IgG antibody were detected by enzyme-linked immunosorbent assay. | 25479069 | 2014 |
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0.060 | AlteredExpression | disease | BEFREE | The study validated whether OPN expressions correlate with Helicobacter pylori-related chronic gastric inflammation and the precancerous change as intestinal metaplasia (IM). | 21585607 | 2011 |