SPP1, secreted phosphoprotein 1, 6696

N. diseases: 824; N. variants: 13
Disease: Recurrent tumor ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0521158
Disease: Recurrent tumor
Recurrent tumor 		0.050 Biomarker phenotype BEFREE RNA expression levels of secreted phosphoprotein 1, the gene that encodes OPN, correlate with poor prognosis in patients with colorectal cancer and are elevated in chemotherapy-treated patients who experience tumor recurrence vs. no recurrence. 29957058 2019
CUI: C0521158
Disease: Recurrent tumor
Recurrent tumor 		0.050 Biomarker phenotype BEFREE Osteopontin and CD44 play important roles in the development and progression of meningioma and can be used as prognostic markers for tumor recurrence and progression as well as therapeutic targets for the development of new drugs. 29504367 2018
CUI: C0521158
Disease: Recurrent tumor
Recurrent tumor 		0.050 AlteredExpression phenotype BEFREE Osteopontin expressed by TAMs is a valuable independent predictor of tumor recurrence and survival in patients with non-small cell lung cancer. 25725928 2015
CUI: C0521158
Disease: Recurrent tumor
Recurrent tumor 		0.050 AlteredExpression phenotype BEFREE Plasma OPN levels appeared to correlate with tumor hypoxia in HNSCC patients and may serve as noninvasive tests to identify patients at high risk for tumor recurrence. 12538452 2003
CUI: C0521158
Disease: Recurrent tumor
Recurrent tumor 		0.050 AlteredExpression phenotype BEFREE The OPN overexpression was associated closely with alpha-fetoprotein elevation (P = 0.001), p53 mutation (P = 0.021), larger tumors (P = 0.002), high-grade HCC (P < 0.001), late-stage HCC (P < 0.001), early tumor recurrence and/or metastasis (P = 0.003), and a lower 10-year survival rate (P = 0.00013). 12833464 2003