BRCA1, BRCA1 DNA repair associated, 672

N. diseases: 747; N. variants: 2600
Disease: Climacteric discomfort ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1306878
Disease: Climacteric discomfort
Climacteric discomfort 		0.020 GeneticVariation phenotype BEFREE Prophylactic surgeries of the reproductive organs have a negative effect on the QoL and psychosocial functioning of women with the <i>BRCA1/2</i> mutations, as they increase the severity of depressive and climacteric symptoms. 31818005 2019
CUI: C1306878
Disease: Climacteric discomfort
Climacteric discomfort 		0.020 GeneticVariation phenotype BEFREE BRCA1/2 mutation carriers reported low levels of climacteric symptoms (mean 10.28 [SD 6.45], and being highly self-compassionate and physically fit. 29290209 2018