Disease: Thyroid Neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE In Korea, most thyroid cancer is the classic papillary type and the BRAF(V600E) mutation is highly prevalent. 17054470 2006
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE Expression of haem oxygenase-1 correlates with tumour aggressiveness and BRAF V600E expression in thyroid cancer. 25262966 2015
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE They also potently blocked MEK phosphorylation in human thyroid cancer cell lines with either RET/PTC1 (TPC1) or BRAF(V600E) (NPA, ARO, and FRO) mutations. 16551863 2006
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE Hence, recent research efforts have been performed trying to explore several inhibitors of the V600E mutation-containing BRAF kinase as potential therapeutic options in thyroid cancer refractory to standard interventions. 30481266 2019
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE We further demonstrate that upfront combined inhibition of FAK and Src synergistically inhibits growth and invasion, and induces apoptosis in a panel of BRAF- and RAS-mutant thyroid cancer cell lines. 30531837 2019
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE The BRAF mutation may influence the expression patterns of molecular markers that are related to the development and progression of thyroid cancer. 16772349 2006
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE Polymerase chain reaction was used to amplify exon 15 of the BRAF gene from paraffin-embedded thyroid tumor specimens, followed by direct sequencing to detect the BRAF(V600E) mutation. 22190222 2012
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE To analyze FTH samples for known recurrent genetic and epigenetic driver events in thyroid neoplasms such as activating mutations in proto-oncogenes BRAF and NRAS and promoter hypermethylation of tumor suppressor genes CDKN2A, PTEN, and RASSF1A. 25229773 2014
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE The effect of activating somatic mutations in the KRAS and BRAF genes on the responsiveness to sunitinib was evaluated in a panel of thyroid cancer cell lines harboring wild-type KRAS and BRAF genes, the RET/PTC1 rearrangement, the G12R KRAS, or the V600E BRAF mutation. 22442268 2012
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN Mutational activation of BRAF is not a major event in sporadic childhood papillary thyroid carcinoma. 15968271 2005
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE This study explores the possibility of building AI models without precise pixel-level annotation in prediction of the tumor size, extrathyroidal extension, lymph node metastasis, cancer stage and BRAF mutation in thyroid cancer diagnosis, providing the patients' background information, histopathological and immunohistochemical tissue images. 29293907 2018
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE These results reveal a novel (V600E)BRAF-induced mechanism in thyroid tumours progression and provides a rationale for using the PLX4720 inhibitor to target (V600E)BRAF signalling to effectively control progression of thyroid cancer. 23435375 2013
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE The influence of the BRAF V600E mutation in thyroid cancer cell lines on the anticancer effects of 5-aminoimidazole-4-carboxamide-ribonucleoside. 21795305 2011
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression. 20498063 2010
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE To explore these effects, differences in the subcellular localization of wild-type and mutant BRAF in thyroid cancer were investigated. 20926530 2011
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE These findings underscore the importance of functional studies to characterize the role of BRAF mutations associated with thyroid cancer. 18697864 2008
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE This study analyzed TERT promoter mutations in various thyroid tumors and examined their relationship with clinicopathologic factors and the BRAF(V600E) mutation in PTC cases. 27184112 2016
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE AZD6244 potently inhibited MEK 1/2 activity in thyroid cancer cell lines regardless of BRAF mutation status, as evidenced by reduced ERK phosphorylation. 17878251 2007
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE Somatic mutations in established thyroid cancer genes were detected in 14 of 22 (64%) tumors and included recurrent mutations in BRAF, TP53 and RAS-family genes (6 cases each), as well as PIK3CA (2 cases) and single cases of CDKN1B, CDKN2C, CTNNB1 and RET mutations. 25576899 2015
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas. 14602780 2003
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE BRAF mutation-selective inhibition of thyroid cancer cells by the novel MEK inhibitor RDEA119 and genetic-potentiated synergism with the mTOR inhibitor temsirolimus. 21351275 2010
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas. 15145515 2004
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE Patients with RAIR, BRAF mutant thyroid cancer. 30256977 2019
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE BRAF provides signals crucial for proliferation of thyroid carcinoma cells spontaneously harboring the (V600E)BRAF mutation and, therefore, BRAF suppression might have therapeutic potential in (V600E)BRAF-positive thyroid cancer. 16533790 2006
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE The aim of this study was to determine whether combined detection of BRAF(V600E) mutation and methylation markers on FNABs could improve the diagnostic accuracy of thyroid cancer. 24588959 2014