|
Thyroid Neoplasm
|
0.700 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Thyroid Neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas.
|
14602780 |
2003 |
|
Thyroid Neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We analyzed BRAF gene mutation at codon 599 in thyroid tumors using mutant-allele-specific PCR and in 10 thyroid tumor cell lines by DNA sequencing of the PCR-amplified exon 15.
|
12907632 |
2003 |
|
Thyroid Neoplasm
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
BRAF mutation in papillary thyroid carcinoma.
|
12697856 |
2003 |
|
Thyroid Neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma.
|
12670889 |
2003 |
|
Thyroid Neoplasm
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma.
|
12670889 |
2003 |
|
Thyroid Neoplasm
|
0.700 |
Biomarker
|
disease |
BEFREE |
We analyzed exons 11 and 15 of BRAF gene in six human thyroid cancer cell lines and 207 paraffin-embedded thyroid tumor tissues.
|
12970315 |
2003 |
|
Thyroid Neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas.
|
15145515 |
2004 |
|
Thyroid Neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We examined BRAF(T1796A) in 21 patients with thyroid tumors using leftover cells in the needle at the preoperative FNAB.
|
15671769 |
2004 |
|
Thyroid Neoplasm
|
0.700 |
Biomarker
|
disease |
LHGDN |
These data clearly confirm that BRAF(V599E) is the more common genetic alteration found to date in adult sporadic PTCs, that it is unique for this thyroid cancer histotype, and that it might drive the development of PTCs of the classic papillary subtype.
|
15126572 |
2004 |
|
Thyroid Neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These data clearly confirm that BRAF(V599E) is the more common genetic alteration found to date in adult sporadic PTCs, that it is unique for this thyroid cancer histotype, and that it might drive the development of PTCs of the classic papillary subtype.
|
15126572 |
2004 |
|
Thyroid Neoplasm
|
0.700 |
Biomarker
|
disease |
BEFREE |
In the present study, the genetic analysis of BRAF in an Italian cohort of 65 thyroid tumours with corresponding normal tissues and 21 thyroid benign disorders is reported.
|
15272920 |
2004 |
|
Thyroid Neoplasm
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Alternative mutations of BRAF, RET and NTRK1 are associated with similar but distinct gene expression patterns in papillary thyroid cancer.
|
15273715 |
2004 |
|
Thyroid Neoplasm
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
A similar inverse correlation of RASSF1A methylation with BRAF mutation was seen in thyroid tumor cell lines.
|
14996725 |
2004 |
|
Thyroid Neoplasm
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Mutational activation of BRAF is not a major event in sporadic childhood papillary thyroid carcinoma.
|
15968271 |
2005 |
|
Thyroid Neoplasm
|
0.700 |
Biomarker
|
disease |
BEFREE |
BRAF copy number gains in thyroid tumors detected by fluorescence in situ hybridization.
|
16199894 |
2005 |
|
Thyroid Neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
BRAF mutation occurs later in thyroid tumor progression and is restricted mainly to PTC and anaplastic thyroid carcinoma.
|
15980887 |
2005 |
|
Thyroid Neoplasm
|
0.700 |
Biomarker
|
disease |
BEFREE |
Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer.
|
15630448 |
2005 |
|
Thyroid Neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The BRAF(V600E) mutation was detected in tumour samples from 31 of 60 conventional micro-PTC patients (52%), but was not detected in patients with other types of thyroid tumours.
|
16268813 |
2005 |
|
Thyroid Neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was the quantitative assessment of promoter hypermethylation and its relation to the BRAF mutation in thyroid tumors.
|
15840741 |
2005 |
|
Thyroid Neoplasm
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer.
|
16174717 |
2005 |
|
Thyroid Neoplasm
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Molecular classification of papillary thyroid carcinoma: distinct BRAF, RAS, and RET/PTC mutation-specific gene expression profiles discovered by DNA microarray analysis.
|
16007166 |
2005 |
|
Thyroid Neoplasm
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
Alterations of the BRAF gene in thyroid tumors.
|
16299399 |
2005 |
|
Thyroid Neoplasm
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
BRAF mutation occurs later in thyroid tumor progression and is restricted mainly to PTC and anaplastic thyroid carcinoma.
|
15980887 |
2005 |
|
Thyroid Neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We isolated genomic DNA from primary thyroid tumors and paired lymph node metastases and performed direct sequencing of exon 15 of the BRAF gene mutation that carries the T1799A mutation.
|
15998781 |
2005 |