|
Carcinoma of lung
|
0.700 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Carcinoma of lung
|
0.700 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
|
Carcinoma of lung
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We sought to determine the frequency of BRAF mutations in human lung cancer pathogenesis.
|
12460919 |
2002 |
|
Carcinoma of lung
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Although >90% of BRAF mutations in melanoma involve codon 599 (57 of 60), 8 of 9 BRAF mutations reported to date in NSCLC are non-V599 (89%; P < 10(-7)), strongly suggesting that BRAF mutations in NSCLC are qualitatively different from those in melanoma; thus, there may be therapeutic differences between lung cancer and melanoma in response to RAF inhibitors.
|
12460918 |
2002 |
|
Carcinoma of lung
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
We sought to determine the frequency of BRAF mutations in human lung cancer pathogenesis.
|
12460919 |
2002 |
|
Carcinoma of lung
|
0.700 |
GeneticVariation
|
disease |
UNIPROT |
We sought to determine the frequency of BRAF mutations in human lung cancer pathogenesis.
|
12460919 |
2002 |
|
Carcinoma of lung
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
BRAF and RAS mutations in human lung cancer and melanoma.
|
12460918 |
2002 |
|
Carcinoma of lung
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
Mutations of the BRAF gene in human cancer.
|
12068308 |
2002 |
|
Carcinoma of lung
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Although a few Caucasian lung cancer patients harbored BRAF mutations, there have been no reports about the BRAF mutation in Japanese patients with lung cancer.
|
16376942 |
2006 |
|
Carcinoma of lung
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These data, together with the nonoverlapping pattern of EGFR and BRAF mutations in human lung cancer, suggest that these lesions define distinct clinical entities whose treatment should be guided by prospective real-time genotyping.
|
19010912 |
2008 |
|
Carcinoma of lung
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
Genetic predictors of MEK dependence in non-small cell lung cancer.
|
19010912 |
2008 |
|
Carcinoma of lung
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines.
|
19238210 |
2009 |
|
Carcinoma of lung
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Consistent with earlier reports, our results show that KRAS and BRAF mutation frequencies in colorectal cancer were 44.3% and 13.0%, respectively, while EGFR mutations were detected in 11.1% of the lung cancer specimens.
|
21943394 |
2011 |
|
Carcinoma of lung
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The incidence of BRAF mutations other than V600E is significantly higher in lung cancer than in melanoma.
|
21483012 |
2011 |
|
Carcinoma of lung
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The role of KRAS and BRAF mutations and ALK rearrangement in lung cancer-targeted therapy, are also reviewed.
|
21463141 |
2011 |
|
Carcinoma of lung
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations.
|
21483012 |
2011 |
|
Carcinoma of lung
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
BRAF(L597) mutations in melanoma are associated with sensitivity to MEK inhibitors.
|
22798288 |
2012 |
|
Carcinoma of lung
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Kinase-impaired BRAF mutations in lung cancer confer sensitivity to dasatinib.
|
22649091 |
2012 |
|
Carcinoma of lung
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1.
|
22773810 |
2012 |
|
Carcinoma of lung
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
A patient with BRAF V600E lung adenocarcinoma responding to vemurafenib.
|
22743296 |
2012 |
|
Carcinoma of lung
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial.
|
22608338 |
2012 |
|
Carcinoma of lung
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this study, using both novel and established technologies, we developed a clinically practical assay to survey the status of three frequently mutated genes in lung cancer (EGFR, K-ras and TP53) and two genes (BRAF and β-catenin) with known hotspot mutations in many other cancers.
|
22407457 |
2012 |
|
Carcinoma of lung
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
Kinase-impaired BRAF mutations in lung cancer confer sensitivity to dasatinib.
|
22649091 |
2012 |
|
Carcinoma of lung
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
Lung adenocarcinoma with BRAF G469L mutation refractory to vemurafenib.
|
24035431 |
2013 |
|
Carcinoma of lung
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
Molecular characterization of acquired resistance to the BRAF inhibitor dabrafenib in a patient with BRAF-mutant non-small-cell lung cancer.
|
23524406 |
2013 |