Disease: Carcinoma of lung ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121913351
rs121913351
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease:
Carcinoma of lung 		0.800 GeneticVariation UNIPROT Molecular testing for selection of patients with lung cancer for epidermal growth factor receptor and anaplastic lymphoma kinase tyrosine kinase inhibitors: American Society of Clinical Oncology endorsement of the College of American Pathologists/International Association for the study of lung cancer/association for molecular pathology guideline. 25311215 2014
dbSNP: rs121913351
rs121913351
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease:
Carcinoma of lung 		0.800 GeneticVariation UNIPROT Guideline Recommendations for Testing of ALK Gene Rearrangement in Lung Cancer: A Proposal of the Korean Cardiopulmonary Pathology Study Group. 24627688 2014
dbSNP: rs121913351
rs121913351
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease:
Carcinoma of lung 		0.800 GeneticVariation UNIPROT Non-small cell lung cancer and precision medicine: a model for the incorporation of genomic features into clinical trial design. 24846033 2014
dbSNP: rs121913351
rs121913351
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease:
Carcinoma of lung 		0.800 GeneticVariation UNIPROT Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology. 23562183 2013
dbSNP: rs121913351
rs121913351
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease:
Carcinoma of lung 		0.800 GeneticVariation UNIPROT Guideline Recommendations for EGFR Mutation Testing in Lung Cancer: Proposal of the Korean Cardiopulmonary Pathology Study Group. 23667368 2013
dbSNP: rs121913351
rs121913351
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease:
Carcinoma of lung 		A 0.800 CausalMutation CLINVAR Clinical, pathologic, and biologic features associated with BRAF mutations in non-small cell lung cancer. 23833300 2013
dbSNP: rs121913351
rs121913351
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease:
Carcinoma of lung 		A 0.800 CausalMutation CLINVAR Kinase-impaired BRAF mutations in lung cancer confer sensitivity to dasatinib. 22649091 2012
dbSNP: rs121913351
rs121913351
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease:
Carcinoma of lung 		A 0.800 CausalMutation CLINVAR Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations. 21483012 2011
dbSNP: rs121913351
rs121913351
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease:
Carcinoma of lung 		A 0.800 CausalMutation CLINVAR Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines. 19238210 2009
dbSNP: rs121913351
rs121913351
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease:
Carcinoma of lung 		A 0.800 CausalMutation CLINVAR Genetic predictors of MEK dependence in non-small cell lung cancer. 19010912 2008
dbSNP: rs121913351
rs121913351
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease:
Carcinoma of lung 		A 0.800 CausalMutation CLINVAR BRAF and RAS mutations in human lung cancer and melanoma. 12460918 2002
dbSNP: rs121913351
rs121913351
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease:
Carcinoma of lung 		A 0.800 CausalMutation CLINVAR Missense mutations of the BRAF gene in human lung adenocarcinoma. 12460919 2002
dbSNP: rs121913351
rs121913351
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease:
Carcinoma of lung 		A 0.800 CausalMutation CLINVAR Mutations of the BRAF gene in human cancer. 12068308 2002
dbSNP: rs121913351
rs121913351
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease:
Carcinoma of lung 		0.800 GeneticVariation UNIPROT Missense mutations of the BRAF gene in human lung adenocarcinoma. 12460919 2002
dbSNP: rs113488022
rs113488022
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease:
Carcinoma of lung 		0.750 GeneticVariation BEFREE Accordingly, the combination of MEK inhibitor with EGFR inhibitor was effective at shrinking tumors in mouse model of BRAF non-V600E mutant lung cancer. 29348459 2018
dbSNP: rs113488022
rs113488022
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease:
Carcinoma of lung 		0.750 GeneticVariation BEFREE Success of this design of clinical trials and practice was first demonstrated in EGFR inhibitor trials in lung cancer and has since been incorporated into subsequent targeted therapy trials including ALK-, ROS1-, and BRAF V600E-targeted therapies. 28786099 2017
dbSNP: rs113488022
rs113488022
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease:
Carcinoma of lung 		T 0.750 CausalMutation CLINVAR Clinical, pathologic, and biologic features associated with BRAF mutations in non-small cell lung cancer. 23833300 2013
dbSNP: rs113488022
rs113488022
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease:
Carcinoma of lung 		0.750 GeneticVariation BEFREE BRAF V600E is an emerging drug target in lung cancer, but the clinical significance of non-V600 BRAF mutations in lung cancer and other malignancies is less clear. 24035431 2013
dbSNP: rs113488022
rs113488022
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease:
Carcinoma of lung 		T 0.750 CausalMutation CLINVAR Molecular characterization of acquired resistance to the BRAF inhibitor dabrafenib in a patient with BRAF-mutant non-small-cell lung cancer. 23524406 2013
dbSNP: rs113488022
rs113488022
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease:
Carcinoma of lung 		T 0.750 CausalMutation CLINVAR Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial. 22608338 2012
dbSNP: rs113488022
rs113488022
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease:
Carcinoma of lung 		T 0.750 CausalMutation CLINVAR Kinase-impaired BRAF mutations in lung cancer confer sensitivity to dasatinib. 22649091 2012
dbSNP: rs113488022
rs113488022
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease:
Carcinoma of lung 		T 0.750 CausalMutation CLINVAR A patient with BRAF V600E lung adenocarcinoma responding to vemurafenib. 22743296 2012
dbSNP: rs113488022
rs113488022
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease:
Carcinoma of lung 		T 0.750 CausalMutation CLINVAR Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1. 22773810 2012
dbSNP: rs113488022
rs113488022
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease:
Carcinoma of lung 		0.750 GeneticVariation BEFREE The incidence of BRAF mutations other than V600E is significantly higher in lung cancer than in melanoma. 21483012 2011
dbSNP: rs113488022
rs113488022
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease:
Carcinoma of lung 		T 0.750 CausalMutation CLINVAR The incidence of BRAF mutations other than V600E is significantly higher in lung cancer than in melanoma. 21483012 2011