Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The objective of the article is to evaluate KRAS and BRAF mutations as potential genetic markers for early detection of malignant transformation, we used an ultrasensitive technique to detect tissue expression of KRAS and BRAF mutations in endoscopic biopsies from 61 adult patients under follow-up after treatment for EA.
|
28873491 |
2018 |
Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
In melanoma, activation of the mitogen-activated protein kinase (MAPK) pathway driven by mutant BRAF or NRAS is a primary cause of malignant transformation.
|
27270434 |
2017 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The expression of the nuclear and cytoplasmic forms of p16 represent two independent mechanisms, and both seemed to control proliferation in response to oncogenic stimuli, protecting the cell from malignant transformation in BRAF-mutated GISTs.
|
28034324 |
2017 |
Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Our results also provide evidence that--just as BRAF V600E mutations in hyperplastic polyps and benign nevi- a mutated driver gene does not imply malignant behavior per se but may set the basis for malignant transformation.
|
26493284 |
2016 |
Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
As mutant BRAF alone is insufficient to drive malignant transformation in other histological cancers, it suggests that individual tumours utilise largely differing patterns of genetic somatic mutations to coalesce with BRAF V(600)E to drive pathogenesis of malignant HCLc disease.
|
26871591 |
2016 |
Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
This case suggests that the BRAF V600E mutation may be involved in the malignant transformation to glioblastoma.
|
26404554 |
2016 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Mitogen-Inducible Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal Growth Factor Receptor and Thereby Limits Malignant Transformation.
|
26065894 |
2015 |
Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The molecular profile of the adenocarcinoma showed a mutation in KRAS and wild-type BRAF, which might be associated with malignant transformation of intracranial mature teratomas.
|
25039399 |
2015 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our findings suggest that the BRAF pathway may contribute to the pathogenesis or malignant transformation of histiocytic and dendritic cell neoplasms.
|
24720374 |
2014 |
Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Activation of the MAPK pathway as a result of activating mutations in BRAF is commonly seen in melanoma though it alone is not sufficient to cause malignant transformation of melanocytes.
|
23554059 |
2013 |
Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
In this series the presence of a BRAF- or NRAS mutation in a nevus was not associated with the risk of malignant transformation.
|
23861977 |
2013 |
Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Mutation in the BRAF oncogene is a key step in malignant transformation within the methylator pathway to colorectal cancer.
|
22228154 |
2012 |
Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
BRAF mutations and RET or NTRK1 rearrangements were identified as causing events that drive the malignant transformation of the thyroid follicular cell.
|
20640859 |
2010 |
Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
In summary, these data demonstrate that a subpopulation of melanocytes possesses the ability to survive BRAF(V600E)-induced senescence, and suggest that p53 inactivation may promote malignant transformation of these cells.
|
19389934 |
2009 |
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
In vitro and in vivo models have demonstrated that overexpression of activated BRAF induces malignant transformation and aggressive tumour behaviour.
|
17179987 |
2007 |
Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
These findings suggest that mutations of the BRAF gene are partly involved in the malignant transformation of the endometrium.
|
16144912 |
2005 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
BRAF encodes a RAS-regulated serine/threonine kinase that mediates the pathway for cell growth and malignant transformation.
|
14719068 |
2004 |
Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Our findings of a high frequency of BRAF mutations at codon 599 in benign melanocytic lesions of the skin indicate that this mutation is not sufficient by itself for malignant transformation.
|
14501284 |
2003 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Three BRAF mutations identified in this study are novel, altering residues important in AKT-mediated BRAF phosphorylation and suggesting that disruption of AKT-induced BRAF inhibition can play a role in malignant transformation.
|
12460918 |
2002 |