TRIM21, tripartite motif containing 21, 6737

N. diseases: 229; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001430
Disease: Adenoma
Adenoma
0.100 Biomarker group BEFREE In addition, observed association between SSA/P with advanced conventional neoplasia (but not low-grade adenomas) suggests 2 distinct groups of patient predisposition, one with both advanced conventional and important serrated precursors (SSA/P) and the other largely restricted to nonadvanced conventional adenomas and HPs only. 28723863 2018
CUI: C0001430
Disease: Adenoma
Adenoma
0.100 Biomarker group BEFREE The 30 seconds additional observation with LCI improved the detection of adenoma and SSA/P in the right-sided colon. 30116263 2018
CUI: C0001430
Disease: Adenoma
Adenoma
0.100 Biomarker group BEFREE To determine whether an educational intervention that improved adenoma detection rate (ADR) could improve SSA/P detection rate after reclassification of previously termed "hyperplastic" polyps. 28444509 2017
CUI: C0001430
Disease: Adenoma
Adenoma
0.100 Biomarker group BEFREE The gut microbiome, including relative abundance of Fusobacteria, did not differ between TA and SSA/P, suggesting that Fusobacteria may contribute to both the serrated pathway and the adenoma-carcinoma sequence. 27125587 2016
CUI: C0001430
Disease: Adenoma
Adenoma
0.100 Biomarker group BEFREE BRAF mutation was more frequent, whereas KRAS mutation was less frequent in the SSA/P series as compared with the adenoma series. 24925057 2015
CUI: C0001430
Disease: Adenoma
Adenoma
0.100 GeneticVariation group BEFREE We consider pedunculated serrated polyp showing features of SSA/P as a previously undescribed form of serrated adenoma/polyp in the spectrum of serrated neoplasia, which might represent a pedunculated variant of SSA/P or a precursor lesion of proximally located traditional serrated adenomas in the earliest stage. 23648458 2013
CUI: C0001430
Disease: Adenoma
Adenoma
0.100 Biomarker group BEFREE Its sensitivity for advanced precancers (AA and SSA) ≥1 cm was 57%, for >2 cm it was 73%, and for >3 cm it was 83%. 23639600 2013
CUI: C0001430
Disease: Adenoma
Adenoma
0.100 Biomarker group BEFREE These findings support the possibility of annual colonoscopic surveillance, consideration for colectomy when SSA/P or adenomas are encountered and frequent postoperative endoscopic surveillance of the retained colorectum. 22490521 2013
CUI: C0001430
Disease: Adenoma
Adenoma
0.100 Biomarker group BEFREE Most of the polyps (83%) were serrated polyps: microvesicular hyperplastic polyps (HP) (n=156), goblet cell HP (n=25), sessile serrated adenoma/polyps (SSA/P) (n=110), SSA/P with cytologic dysplasia (n=28), and traditional serrated adenomas (n=18). 22510757 2012
CUI: C0001430
Disease: Adenoma
Adenoma
0.100 GeneticVariation group BEFREE A BRAF mutation was present in 82% of serrated carcinomas (SCas), 62% of serrated adenomas (SAs), 83% of serrated polyps with abnormal proliferation (SPAPs-syn. sessile serrated adenoma [SSA]), 76% of microvesicular serrated polyps (MVSPs), and was not found in any of the histologic categories of the traditional adenoma-carcinoma sequence. 17122504 2006