TRIM21, tripartite motif containing 21, 6737

N. diseases: 229; N. variants: 1
Disease: Connective Tissue Diseases ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009782
Disease: Connective Tissue Diseases
Connective Tissue Diseases 		0.070 Biomarker group BEFREE For distinguishing DM/PM from other CTDs, the sensitivity, specificity, and positive predictive value (PPV) for anti-MDA5 were 28.46, 99.00, and 97.37%, respectively, with a positive likelihood ratio (LR+) of 28.46; they were 46.15, 58.00, and 58.82%, respectively, for anti-Ro-52 with an LR+ of 1.10. 30616054 2019
CUI: C0009782
Disease: Connective Tissue Diseases
Connective Tissue Diseases 		0.070 Biomarker group BEFREE The majority of patients with ILD and anti-Ro52 had no established connective tissue disease (78%), and one-third had no rheumatologic symptoms. 31718649 2019
CUI: C0009782
Disease: Connective Tissue Diseases
Connective Tissue Diseases 		0.070 Biomarker group BEFREE Tests to exclude connective tissue diseases were positive for the anti-Ro-52/TRIM-21 autoantibody. 31168306 2019
CUI: C0009782
Disease: Connective Tissue Diseases
Connective Tissue Diseases 		0.070 Biomarker group BEFREE In morphea, anti-TRIM21/Ro52 antibodies were found in 4 patients (36.4%) and resulted to be the most frequently detected antibodies also in two groups of SSC and CTD. 27706114 2018
CUI: C0009782
Disease: Connective Tissue Diseases
Connective Tissue Diseases 		0.070 Biomarker group BEFREE Studies using patient sera have shown a correlation between the generation of Ro52-autoAbs and the clinical morbidity and severity of CTD with ILD. 29989658 2018
CUI: C0009782
Disease: Connective Tissue Diseases
Connective Tissue Diseases 		0.070 Biomarker group BEFREE We enrolled patients with anti-Ro52-positive CTDs, ANA-positive CTDs, and healthy subjects in this cross-sectional study. 27193468 2017
CUI: C0009782
Disease: Connective Tissue Diseases
Connective Tissue Diseases 		0.070 Biomarker group BEFREE When first seen at the age of 15 y she was found to have an unclassified connective tissue disorder and to be seropositive for anti Ro/SSA and U1 RNP. 9104738 1997