|
Congenital heart block
|
0.100 |
Biomarker
|
disease |
BEFREE |
Benefits of fetal echocardiographic surveillance in pregnancies at risk of congenital heart block: single-center study of 212 anti-Ro52-positive pregnancies.
|
30620419 |
2019 |
|
Congenital heart block
|
0.100 |
Biomarker
|
disease |
BEFREE |
Congenital heart block (CHB) may develop in fetuses of Ro/SSA autoantibody-positive women.
|
30808622 |
2019 |
|
Congenital heart block
|
0.100 |
Biomarker
|
disease |
BEFREE |
Anti-Ro52 antibody level is an important marker of fetal congenital heart block risk in anti-Ro/SSA antibody positive pregnancy.
|
28880700 |
2018 |
|
Congenital heart block
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of Natural Killer Cell Ligand Polymorphism HLA-C Asn80Lys With the Development of Anti-SSA/Ro-Associated Congenital Heart Block.
|
29045069 |
2017 |
|
Congenital heart block
|
0.100 |
Biomarker
|
disease |
BEFREE |
Low titer, isolated anti Ro/SSA 60 kd antibodies is correlated with positive pregnancy outcomes in women at risk of congenital heart block.
|
28204891 |
2017 |
|
Congenital heart block
|
0.100 |
Biomarker
|
disease |
BEFREE |
We traced the evolution of two anti-Ro52 autoantibodies isolated from circulating IgG1-switched B-cells from an asymptomatic mother of a child with third degree congenital heart block.
|
28118945 |
2017 |
|
Congenital heart block
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cardiac fibroblast transcriptome analyses support a role for interferogenic, profibrotic, and inflammatory genes in anti-SSA/Ro-associated congenital heart block.
|
28626076 |
2017 |
|
Congenital heart block
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
While the relationship between maternal connective tissue diseases and neonatal rashes was described in the 1960s and congenital heart block in the 1970s, the "culprit" antibody reactivity to the SSA/Ro-SSB/La ribonucleoprotein complex was not identified until the 1980s.
|
28709760 |
2017 |
|
Congenital heart block
|
0.100 |
Biomarker
|
disease |
BEFREE |
We analyzed occurrence of postnatal DCM among children with high-degree congenital heart block (CHB) and mothers with anti-SSA and/or anti-SSB antibodies.
|
28843719 |
2017 |
|
Congenital heart block
|
0.100 |
Biomarker
|
disease |
BEFREE |
The small for gestational age rate is higher probably because of SLE not because anti-Ro/SS-A •Preterm delivery happens in anti-Ro/SS-A patients at the same rate as in the general population if no complications such as congenital heart block or intrauterine growth restriction occur.
|
28138914 |
2017 |
|
Congenital heart block
|
0.100 |
Biomarker
|
disease |
BEFREE |
Only 2% of mothers positive for anti-SSA/Ro (Ro) antibodies have children with congenital heart block (CHB).
|
25994441 |
2015 |
|
Congenital heart block
|
0.100 |
Biomarker
|
disease |
BEFREE |
The main aim of this study was to identify foetal susceptibility genes on chromosome six for Ro/SSA autoantibody-mediated congenital heart block.
|
24354957 |
2014 |
|
Congenital heart block
|
0.100 |
Biomarker
|
disease |
BEFREE |
Role of the urokinase plasminogen activator receptor in mediating impaired efferocytosis of anti-SSA/Ro-bound apoptotic cardiocytes: Implications in the pathogenesis of congenital heart block.
|
20558828 |
2010 |
|
Congenital heart block
|
0.100 |
Biomarker
|
disease |
BEFREE |
The objective of this study was to identify putative Ro52/60-kDa Ro/SSA antigen (Ro60) epitopes associated with neonatal lupus and congenital heart block.
|
16356190 |
2006 |
|
Congenital heart block
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block.
|
15630133 |
2005 |
|
Congenital heart block
|
0.100 |
Biomarker
|
disease |
BEFREE |
The identified antibodies, which react specifically with the leucine zipper structure of Ro52, will be valuable in further exploration of the mechanisms operating during development of Ro52 antibody-associated congenital heart block.
|
14987746 |
2004 |
|
Congenital heart block
|
0.100 |
Biomarker
|
disease |
BEFREE |
The 52-kDa SSA/Ro (Ro52) ribonucleoprotein is an antigenic target strongly associated with the autoimmune response in mothers whose children develop neonatal lupus and congenital heart block.
|
11069058 |
2000 |
|
Congenital heart block
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although a strong clinical association exists between congenital heart block (CHB) and an immune response to SSA/Ro and SSB/La proteins, a causative role of these antibodies in the pathogenesis is just emerging.
|
9667364 |
1998 |
|
Congenital heart block
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cardiac expression of 52beta, an alternative transcript of the congenital heart block-associated 52-kd SS-A/Ro autoantigen, is maximal during fetal development.
|
9125247 |
1997 |
|
Congenital heart block
|
0.100 |
Biomarker
|
disease |
BEFREE |
Anti-SS-A/Ro antibodies are commonly found in systemic autoimmune diseases such as Sjögren's syndrome and systemic lupus erythematosus, and some of these antibodies appear to be responsible for certain pathological lesions including congenital heart block in neonatal lupus.
|
9125110 |
1997 |
|
Congenital heart block
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This study indicates that placental transfer of anti-Ro(SSA) or anti-La(SSB) alone to the fetus is not sufficient for the expression of congenital complete heart block.
|
8148276 |
1994 |
|
Congenital heart block
|
0.100 |
Biomarker
|
disease |
BEFREE |
Two types of heart block can be recognized: Congenital heart block is associated with maternal anti-Ro/SS-A antibodies and numerous obstetric and neonatal complications.
|
8195531 |
1994 |
|
Congenital heart block
|
0.100 |
Biomarker
|
disease |
BEFREE |
To date, there is a universal association of CCHB with maternal antibodies to SSA/Ro-SSB/La ribonucleoproteins, detectable by high ratio monomer:crosslinker SDS-immunoblot.
|
1285897 |
1993 |
|
Congenital heart block
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the sera of these three women circulating anti-SS-A (Ro) antibodies were detected, which are known to be associated with congenital heart block.
|
1881495 |
1991 |
|
Congenital heart block
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Congenital complete heart block (CCHB) occurs in the offspring of mothers who have the HLA-A1;B8; DR3 haplotype and Ro (SS-A) autoantibodies.
|
2818659 |
1989 |