Disease: Sjogren's Syndrome ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.100 Biomarker disease BEFREE Recent evidences have revealed that anti-SSA/SSB antibodies, the major autoantibodies in Sjögren's syndrome (SS), are produced in salivary glands. 31611218 2020
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.100 Biomarker disease BEFREE All participants in the SICCA registry who were found to have any objective measures of salivary hypofunction, dry eye, focal lymphocytic sialadenitis in minor salivary gland biopsy, or anti-SSA/SSB antibodies were recalled over a window of 2 to 3 years after their baseline examinations to repeat all clinical examinations and specimen collections to determine whether there was any change in phenotypic features and in SS status. 28437595 2018
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.100 Biomarker disease BEFREE E. coli with autodisplayed La/SSB protein was used for an immunoassay of anti-La/SSB antibodies for the diagnosis of Sjögren's syndrome. 28284305 2017
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.100 AlteredExpression disease BEFREE Defective DNA methylation in salivary gland epithelial acini from patients with Sjögren's syndrome is associated with SSB gene expression, anti-SSB/LA detection, and lymphocyte infiltration. 26725749 2016
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.100 Biomarker disease BEFREE The elevated tissue expression of Ro/SSA and La/SSB autoantigens appears to be crucial for the generation and perpetuation of autoimmune humoral responses against these autoantigens in Sjögren's syndrome (SS). 26201309 2015
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.100 GeneticVariation disease BEFREE Targeted deletion of the gene encoding the La autoantigen (Sjögren's syndrome antigen B) in B cells or the frontal brain causes extensive tissue loss. 24190965 2014
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.100 Biomarker disease BEFREE A number of systemic features have also been described and the presence of autoantibodies against the ubiquitously expressed ribonucleoprotein particles Ro (Sjögren's-syndrome-related antigen A - SSA) and La (SSB) further underline the systemic nature of Sjögren's syndrome. 21777618 2011
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.100 Biomarker disease BEFREE Conventional manifestations of fetal Sjogren's antibodies (SSA/SSB) associated cardiac disease include atrioventricular block (AVB), transient sinus bradycardia, endocardial fibroelastosis (EFE) and dilated cardiomyopathy. 19330707 2009
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.100 AlteredExpression disease LHGDN Differential expression of Ro/SSA 60 kDa and La/SSB, but not Ro/SSA 52 kDa, mRNA and protein in minor salivary glands from patients with primary Sjögren's syndrome. 17552056 2007
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.100 Biomarker disease BEFREE Immunoblot analysis on two-dimensional gels using purified anti-La/SSB antibodies revealed that pSS salivary glands contain high levels of post-translationally modified La/SSB autoantigen, while the native form of the protein is recognized faintly, in contrast to normal controls. 17177966 2007
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.100 Biomarker disease BEFREE Thyroiditis, autoantibodies to Ro/SS-A, La/SS-B and ds-DNA was more frequent in the SS-SLE group than in patients with SLE. 17145372 2006
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.100 Biomarker disease BEFREE Fragmentation of autoantigens such as SS-B/La or alfa-fodrin during the process of apoptosis causes the redistribution of these autoantigens, leading to the production of autoantibodies in SS. 17162248 2006
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.100 Biomarker disease BEFREE One hundred forty-nine white patients fulfilling the American-European Consensus Group criteria for SS were divided into 3 subgroups, according to their anti-Ro/SSA and anti-La/SSB status, as follows: group 1 (n = 53), no antibody; group 2 (n = 46), anti-SSA only; group 3 (n = 50), both anti-SSA and anti-SSB. 12905478 2003
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.100 Biomarker disease BEFREE Unmasking the anti-La/SSB response in sera from patients with Sjogren's syndrome by specific blocking of anti-idiotypic antibodies to La/SSB antigenic determinants. 12428060 2002
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.100 Biomarker disease BEFREE Interestingly, the incidence of antibodies to SS-56 was associated with visceral complications in SLE, and roughly half of the 17 SS or SLE patients with no detectable antibodies to SSA and SSB antigens presented measurable antibodies against recombinant SS-56. 11560955 2001
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.100 Biomarker disease BEFREE There was a strong correlation between clinical signs and corresponding autoantibodies such as anti-SSA and -SSB antibodies in Sjögren's syndrome (10 cases), antithyroid peroxidase antibodies in thyroiditis and Graves' disease (10 cases), and parietal cell antibodies in gastric ulcers with maltoma (12 cases). 10205590 1999
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.100 Biomarker disease BEFREE Phage clones selected for the presence of insert both by gene and antigenic analyses were used in the ELISA to detect anti-La/SS-B antibodies from patients with Sjogren's syndrome and SLE. 9237100 1997
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.100 Biomarker disease BEFREE Several different groups of SS sera previously tested for Ro and La(SSB) autoantibodies in clinical diagnostic labs were tested by ELISA with a recombinant human 52 kDa Ro fusion protein. 9150073 1997
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.100 Biomarker disease BEFREE One gene, two transcripts: isolation of an alternative transcript encoding for the autoantigen La/SS-B from a cDNA library of a patient with primary Sjögrens' syndrome. 7964483 1994
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.100 Biomarker disease BEFREE The three mothers were found to suffer from Sjögren's syndrome; they all tested positive for anti-SSA and SSB antibodies and had lymphocyte infiltration into the small salivary gland. 1607484 1992
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.100 Biomarker disease BEFREE SS-B/La is a major antigenic target for autoantibodies in patients with Sjögren's syndrome. 2476998 1989
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.100 Biomarker disease BEFREE Because the SS-A/Ro and SS-B/La autoantibody responses in SS and systemic lupus erythematosus (SLE) show even stronger correlations with HLA alleles, HLA-DR and DQ alleles were examined using restriction fragment length polymorphisms (RFLP) in white and black patients with SS and/or SS having anti-Ro and anti-La antibodies. 2571337 1989