Ovarian Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Routine germline BRCA1 and BRCA2 testing in patients with ovarian carcinoma: analysis of the Scottish real-life experience.
|
29460478 |
2018 |
Ovarian Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Here, we show that this combined approach allows the rapid and reliable detection of both germline and somatic aberrations affecting BRCA1 and BRCA2 in DNA derived from FFPE OCs, enabling improved hereditary cancer risk assessment and clinical treatment of ovarian cancer patients.
|
27767231 |
2017 |
Ovarian Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
BRCA1 and BRCA2 mutation carriers have an 18%-60% and 11%-27% lifetime risk of developing ovarian carcinoma, respectively.
|
24131970 |
2013 |
Ovarian Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Morphologic patterns associated with BRCA1 and BRCA2 genotype in ovarian carcinoma.
|
22193042 |
2012 |
Ovarian Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
BRCA1/BRCA2 mutations are common and the hallmarks of high-grade serous ovarian carcinoma.
|
22790015 |
2012 |
Ovarian Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Four carriers of pathogenic mutations in both BRCA1 and BRCA2 were identified among women who underwent genetic counseling for hereditary susceptibility to breast and ovarian carcinoma at three different Italian institutions.
|
20373018 |
2010 |
Ovarian Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Thus, restoration of BRCA2 due to secondary BRCA2 mutation is involved in acquired drug resistance of BRCA2-mutated ovarian carcinoma.
|
19654294 |
2009 |
Ovarian Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Orbital metastasis from ovarian carcinoma in a patient with BRCA-2 mutation.
|
16855505 |
2006 |
Ovarian Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The identification of germ-line mutations in 2 genes (BRCA1 and BRCA2) responsible for the majority of hereditary ovarian cancers has led an increasing number of women carriers of these mutations to undergo prophylactic oophorectomy (PO) to reduce their risk of subsequent ovarian carcinoma.
|
17001151 |
2006 |
Ovarian Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Women with family histories suggestive of an increased risk of ovarian carcinoma who have not had a deleterious BRCA1 or BRCA2 mutation identified are commonly suggested to consider ovarian carcinoma screening with transvaginal ultrasound and/or assessment of CA 125 levels.
|
15948173 |
2005 |
Ovarian Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Prognostic impact of BRCA1 pathogenic and BRCA1/BRCA2 unclassified variant mutations in patients with ovarian carcinoma.
|
16047333 |
2005 |
Ovarian Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Germline mutations of BRCA1 and BRCA2 in Korean sporadic ovarian carcinoma.
|
16084575 |
2005 |
Ovarian Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Germline mutations in the BRCA1 and BRCA2 genes are associated with an inherited predisposition to breast and ovarian carcinoma, and specific mutations in these genes are found at increased frequency in certain populations.
|
12879478 |
2003 |
Ovarian Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Multiple mechanisms cause nearly universal dysfunction of BRCA1 and/or BRCA2 in hereditary and sporadic ovarian carcinoma.
|
12237285 |
2002 |
Ovarian Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
BRCA-1 and BRCA-2 are tumor suppressor genes in familial breast-ovarian carcinoma syndrome.
|
11550149 |
2001 |
Ovarian Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
BRCA2 mutations were less common than BRCA1 mutations in families with any history of ovarian carcinoma.
|
10717622 |
2000 |
Ovarian Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A patient with breast carcinoma diagnosed at the age of 30 years and ovarian carcinoma diagnosed at the age of 41 years was found to have germline mutations in both the BRCA1 and the BRCA2 genes.
|
9790802 |
1998 |
Ovarian Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Germ-line mutations in the BRCA1 and BRCA2 genes confer a predisposition to breast as well as ovarian carcinoma.
|
9661879 |
1998 |
Ovarian Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In women with breast cancer, mutations in BRCA1 and BRCA2 were associated with a 10-fold increased risk of subsequent ovarian carcinoma (P = .005).
|
9667259 |
1998 |
Ovarian Carcinoma
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
Ovarian Carcinoma
|
0.500 |
CausalMutation
|
disease |
CGI |
|
|
|
Ovarian Carcinoma
|
0.500 |
GenomicAlterations
|
disease |
CGI |
|
|
|