SST, somatostatin, 6750

N. diseases: 535; N. variants: 4
Disease: Seizures ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036572
Disease: Seizures
Seizures 		0.360 AlteredExpression phenotype BEFREE In sharp contrast, layer 5 PNs and somatostatin-expressing INs were gradually and asynchronously recruited into the ictal activity during the course of seizures. 31657482 2020
CUI: C0036572
Disease: Seizures
Seizures 		0.360 AlteredExpression phenotype BEFREE We have shown that sustained vector-mediated hippocampal somatostatin (SST) expression can both block epileptogenesis and reverse seizure susceptibility in fully kindled rats. 30735971 2019
CUI: C0036572
Disease: Seizures
Seizures 		0.360 Biomarker phenotype BEFREE Regional and temporal regulation and role of somatostatin receptor subtypes in the mouse brain following systemic kainate-induced acute seizures. 30685491 2019
CUI: C0036572
Disease: Seizures
Seizures 		0.360 AlteredExpression phenotype BEFREE Somatostatin is expressed widely in the hippocampus and notably in hilar GABAergic neurons that are vulnerable to seizure neuropathology in chronic temporal lobe epilepsy. 28167431 2017
CUI: C0036572
Disease: Seizures
Seizures 		0.360 Biomarker phenotype BEFREE We report a girl with congenital hyperinsulinism due to novel homozygous mutation (c.2041-25 G>A; aberrant splicing mutation) in the ABCC8 gene encoding SUR1 and during somatostatin analog (octreotide) discontinuation developed by nonhypoglycemic seizures. 22876555 2012
CUI: C0036572
Disease: Seizures
Seizures 		0.360 Therapeutic phenotype CTD_human SRA880 did not affect seizure severity and did not reverse the anticonvulsive action of SRIF-14 (1 microM) against pilocarpine-induced seizures, suggesting that hippocampal sst(1) receptors are not involved in the anticonvulsive effects of SRIF-14. 20134357 2010
CUI: C0036572
Disease: Seizures
Seizures 		0.360 Biomarker phenotype CTD_human SRA880 did not affect seizure severity and did not reverse the anticonvulsive action of SRIF-14 (1 microM) against pilocarpine-induced seizures, suggesting that hippocampal sst(1) receptors are not involved in the anticonvulsive effects of SRIF-14. 20134357 2010
CUI: C0036572
Disease: Seizures
Seizures 		0.360 Biomarker phenotype CTD_human Our study suggests that the ability of Ang IV to inhibit pilocarpine-induced convulsions is dependent on somatostatin receptor-2 activation, and is possibly mediated via the inhibition of IRAP resulting in an elevated concentration of somatostatin-14 in the brain. 16771832 2006
CUI: C0036572
Disease: Seizures
Seizures 		0.360 Therapeutic phenotype CTD_human Our study suggests that the ability of Ang IV to inhibit pilocarpine-induced convulsions is dependent on somatostatin receptor-2 activation, and is possibly mediated via the inhibition of IRAP resulting in an elevated concentration of somatostatin-14 in the brain. 16771832 2006
CUI: C0036572
Disease: Seizures
Seizures 		0.360 Biomarker phenotype BEFREE Pharmacological studies show that somatostatin affects electrophysiological properties of neurons, modulates classical neurotransmission and has anticonvulsant properties in experimental models of seizures. 10583466 1999
CUI: C0036572
Disease: Seizures
Seizures 		0.360 Therapeutic phenotype CTD_human [Effect of intracerebral injections of somatostatin and neurotensin on motor functions in seizure]. 7913897 1994
CUI: C0036572
Disease: Seizures
Seizures 		0.360 Biomarker phenotype CTD_human [Effect of intracerebral injections of somatostatin and neurotensin on motor functions in seizure]. 7913897 1994