|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Moreover, phospho-ablated mutant S34A abrogated the ability of p48 to accelerate tumor cell growth in a mouse engraft model.
|
25154617 |
2015 |
|
Colorectal Carcinoma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
The HIP gene encoding a heparin/heparan sulfate interacting protein is mutated in metastatic human colorectal cancer.
|
12632100 |
2003 |
|
Malignant neoplasm of colon and/or rectum
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
The HIP gene encoding a heparin/heparan sulfate interacting protein is mutated in metastatic human colorectal cancer.
|
12632100 |
2003 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
We report that circadian activity, light-induced entrainment, molecular clockwork, as well as melatonin secretion are preserved in the HIP rat model of T2DM.
|
28465284 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Pregnancy can therefore be considered a stress test; diagnosis of HIP can unmask a preexisting susceptibility and consequently a future risk for type 2 diabetes and can be a useful marker of future cardiovascular risk.
|
29730389 |
2018 |
|
XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP E
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
UV-damaged DNA-binding activity (UV-DDB) is deficient in some xeroderma pigmentosum group E individuals due to mutation of the p48 gene, but its role in DNA repair has been obscure.
|
10882109 |
2000 |
|
Malignant neoplasm of breast
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We identified 38 breast cancers in 37 patients from 2013 to 2014 treated at our institution with HIP following lumpectomy for early stage breast cancer.
|
30053864 |
2018 |
|
Non-Small Cell Lung Carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In the present communication, we treated two furin-overexpressing non-small cell carcinoma (NSCLC) cell lines (Calu-6 and HOP-62) with the PC inhibitor CMK (Decanoyl-Arg-Val-Lys-Arg-chloromethylketone).
|
27584082 |
2017 |
|
B-CELL MALIGNANCY, LOW-GRADE
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Using the 650-kb DNA sequence from the minimally deleted region in B-cell chronic lymphocytic leukemia (BCLL), we have identified a new gene, FAM10A4, that maps to the proximal end of the region.
|
12079276 |
2002 |
|
Asthma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Two SNPs in ST13 (rs138335 and rs138337), but not in the other genes, were associated at a nominal level with an increased risk of exacerbations in asthmatics using ICS in the three cohorts studied.
|
25616159 |
2015 |
|
Cardiovascular Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Day-by-Day Variability of Home Blood Pressure and Incident Cardiovascular Disease in Clinical Practice: The J-HOP Study (Japan Morning Surge-Home Blood Pressure).
|
29133364 |
2018 |
|
Xeroderma Pigmentosum
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Xeroderma pigmentosum p48 gene enhances global genomic repair and suppresses UV-induced mutagenesis.
|
10882109 |
2000 |
|
Non-small cell carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In the present communication, we treated two furin-overexpressing non-small cell carcinoma (NSCLC) cell lines (Calu-6 and HOP-62) with the PC inhibitor CMK (Decanoyl-Arg-Val-Lys-Arg-chloromethylketone).
|
27584082 |
2017 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Here we have developed a pipeline for generating PDAC GEMMs of complex genotypes with high efficiency using a single "workhorse" mouse strain expressing Cas9 in the adult pancreas under a p48 promoter.
|
30728464 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In some cell lines, p48 was detected in the nucleus whereas in others it was cytoplasmic, as in one human acinar tumor.
|
10768861 |
2000 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Presence of p48 in three tumor samples predicted responsiveness to IFN.
|
19715403 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We have recently identified HOP hoemobox (HOPX) as a tumor suppressor gene candidate, characterized by tumor-specific promoter DNA hypermethylation in human cancers, and it can remarkably inhibit tumors' aggressive phenotypes.
|
22958219 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Carboxy-terminus Hsc70 interacting protein exerts a tumor inhibition function in head and neck cancer.
|
28731191 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Characterization of FAM10A4, a member of the ST13 tumor suppressor gene family that maps to the 13q14.3 region associated with B-Cell leukemia, multiple myeloma, and prostate cancer.
|
12079276 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
ST13 gene is a proliferation regulator that inhibits tumor growth in CRC and may affect cell migration.
|
23125081 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
HOP positive transfectants remarkably reduced the growth rate and the ability of anchorage-independent growth in soft agar, and moreover suppressed the tumor formation in nude mice compared to controls.
|
17417779 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, HOP may work as a tumor suppressor in a subset of glioblastomas.
|
18507846 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In contrast, p48 seems to act as tumour suppressor in breast carcinoma inhibiting proliferation, favouring apoptosis, and inducing a slight increase of MHC II expression similar to p42.
|
26081906 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In exploring the mechanism of ZD55-ST13 in tumor cell killing, we found that ZD55-ST13-infected SW620 cells formed apoptotic bodies and presented obvious apoptosis phenomena.
|
18355116 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
RFP2, c13ORF1, and FAM10A4 are the most likely tumor suppressor gene candidates for B-cell chronic lymphocytic leukemia.
|
14499696 |
2003 |