|
Acute Promyelocytic Leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Lack of p48 expression could be one of the mechanisms of promyelocytic leukemia cell escape from growth-inhibitory effects of IFN-alpha.
|
9186002 |
1997 |
|
Acute Promyelocytic Leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Previously, conditioned medium P48 has been shown to induce differentiation of HL-60 (human promyelocytic leukemia) cells.
|
10694514 |
2000 |
|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
LHGDN |
ST13 is mostly expressed in colorectal epithelia and adenocarcinoma cells.
|
15637739 |
2005 |
|
Adult Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We studied EBP1, an ErbB3 binding protein, and the effects of p48 and p42 isoforms on the MHC II expression in U87 glioblastoma, M14 melanoma and MCF7 mammary carcinoma cell lines.
|
26081906 |
2015 |
|
Adult Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Regulation of survival in adult hippocampal and glioblastoma stem cell lineages by the homeodomain-only protein HOP.
|
18507846 |
2008 |
|
Alzheimer's Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
Importantly, the logistic regression analysis showed that the HIP/PHG-RSFC with the bilateral MPFC predicted aMCI-conversion to AD.
|
30319395 |
2018 |
|
Alzheimer's Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
These results indicate that HIP-009 cells are physiologically relevant for AD drug screening and hence are loadstars for the establishment of in vitro AD models.
|
27572608 |
2016 |
|
Amyloidosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We also found that diabetic rats expressing amyloid-forming human amylin in the pancreas (the HIP rat model) have increased tissue levels of hypoxia-inducible transcription factors, compared to diabetic rats that express non-amyloid forming rat amylin (the UCD rat model).
|
31739987 |
2020 |
|
Anemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among adolescents living in the Karachi slum, stunting and highly prevalent anaemia delayed AAG2, while stunting, thinness and VAD delayed AAG2.
|
31606907 |
2019 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Here we have developed a pipeline for generating PDAC GEMMs of complex genotypes with high efficiency using a single "workhorse" mouse strain expressing Cas9 in the adult pancreas under a p48 promoter.
|
30728464 |
2019 |
|
Asthma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Two SNPs in ST13 (rs138335 and rs138337), but not in the other genes, were associated at a nominal level with an increased risk of exacerbations in asthmatics using ICS in the three cohorts studied.
|
25616159 |
2015 |
|
Atrial Fibrillation
|
0.010 |
Biomarker
|
disease |
BEFREE |
Compared to BNP, HOP had better value in discriminating the patients at different stages, especially in elderly patients and those with atrial fibrillation, high body mass index, or kidney dysfunction.
|
30405858 |
2018 |
|
B-CELL MALIGNANCY, LOW-GRADE
|
0.020 |
Biomarker
|
disease |
BEFREE |
RFP2, c13ORF1, and FAM10A4 are the most likely tumor suppressor gene candidates for B-cell chronic lymphocytic leukemia.
|
14499696 |
2003 |
|
B-CELL MALIGNANCY, LOW-GRADE
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Using the 650-kb DNA sequence from the minimally deleted region in B-cell chronic lymphocytic leukemia (BCLL), we have identified a new gene, FAM10A4, that maps to the proximal end of the region.
|
12079276 |
2002 |
|
Bipolar Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found that both the MDD and BD groups had decreased RSFC between the ACC_L and the left orbitofrontal cortex (OFC_L) and that the MDD group had decreased RSFC between the SFG_L and the HIP_L, compared with the healthy controls.
|
30069426 |
2018 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Prognostic value of the ubiquitin ligase carboxyl terminus of the Hsc70-interacting protein in postmenopausal breast cancer.
|
27334118 |
2016 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Compound 3g displayed GI50 value 0.865 μM against EKVX (Non-Small Cell Lung Cancer cell line), and 1.20 µM against MDA-MB-468 (Breast Cancer cell Line), while (4c) showed GI50 value 0.34 and 0.96 µM against HOP-92 and EKVX (Non-Small Cell Lung Cancer cell line) and 1.08 µM against MDA-MB-231/ATCC(Breast Cancer cell Line).
|
29962341 |
2019 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
In contrast, p48 seems to act as tumour suppressor in breast carcinoma inhibiting proliferation, favouring apoptosis, and inducing a slight increase of MHC II expression similar to p42.
|
26081906 |
2015 |
|
Carcinogenesis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Forced expression of HOP suppressed tumorigenesis in soft agar in four different squamous cell carcinoma cell lines.
|
18234960 |
2008 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Src family kinases, p53, mTOR and C-terminus of HSC70 interacting protein (CHIPs) are some examples associated with protein misfolding and tumorigenesis.
|
20653514 |
2010 |
|
Carcinogenesis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Taken together, these results indicate that HIP gene overexpression is associated with thyroid carcinogenesis and strongly suggest its involvement in thyroid cell growth regulation.
|
9788632 |
1998 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Multifaceted C-terminus of HSP70-interacting protein regulates tumorigenesis via protein quality control.
|
30600426 |
2019 |
|
Carcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The analysis of surgically removed thyroid tumors showed overexpression of HIP gene in all of the carcinomas, independent of the histotype, although the largest increase in HIP expression was observed in the undifferentiated forms.
|
9788632 |
1998 |
|
Carcinoma of lung
|
0.050 |
Biomarker
|
disease |
BEFREE |
In the 60 cell lines of the NCI Developmental Therapeutic Anticancer Screen (the NCI-60), whose whole genome transcriptome and mutations have recently been characterized, we discovered two human lung cancer cell lines deficient for TDP1 (NCI_H522 and HOP_62).
|
24355542 |
2014 |
|
Carcinoma of lung
|
0.050 |
Biomarker
|
disease |
BEFREE |
Here, we show that human lung cancer cell lines can be rendered sensitive to ionizing radiation (IR) by RNAi knockdown of C-terminus of Hsc70-interacting protein (CHIP/STUB1), a U-box-type E3 ubiquitin ligase that targets a number of stress-induced proteins.
|
28232384 |
2017 |