|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Carboxy-terminus Hsc70 interacting protein exerts a tumor inhibition function in head and neck cancer.
|
28731191 |
2017 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Moreover, phospho-ablated mutant S34A abrogated the ability of p48 to accelerate tumor cell growth in a mouse engraft model.
|
25154617 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In contrast, p48 seems to act as tumour suppressor in breast carcinoma inhibiting proliferation, favouring apoptosis, and inducing a slight increase of MHC II expression similar to p42.
|
26081906 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We have recently identified HOP hoemobox (HOPX) as a tumor suppressor gene candidate, characterized by tumor-specific promoter DNA hypermethylation in human cancers, and it can remarkably inhibit tumors' aggressive phenotypes.
|
22958219 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
ST13 gene is a proliferation regulator that inhibits tumor growth in CRC and may affect cell migration.
|
23125081 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Decreased expression of CHIP in proliferating cancer cells is in keeping with its proposed tumor suppressor properties, while over-expression of HOP in proliferating cells may contribute to excessive Hsp90 activity and stabilization of client proteins in tumors.
|
22669480 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Presence of p48 in three tumor samples predicted responsiveness to IFN.
|
19715403 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, HOP may work as a tumor suppressor in a subset of glioblastomas.
|
18507846 |
2008 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In conclusion, HOP is a putative TSG that harbors tumor inhibitory activity, and we for the first time showed that the final shutdown process of HOP expression is linked to promoter DNA hypermethylation under the double control of the discrete promoter regions in cancer.
|
18234960 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In exploring the mechanism of ZD55-ST13 in tumor cell killing, we found that ZD55-ST13-infected SW620 cells formed apoptotic bodies and presented obvious apoptosis phenomena.
|
18355116 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
HOP positive transfectants remarkably reduced the growth rate and the ability of anchorage-independent growth in soft agar, and moreover suppressed the tumor formation in nude mice compared to controls.
|
17417779 |
2007 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
HIP expression in human tumors or mouse xenograft tumors compared to normal tissues was assayed by Q-RT-PCR or hybridization of RNA probes to a cancer profiling array.
|
15294024 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
RFP2, c13ORF1, and FAM10A4 are the most likely tumor suppressor gene candidates for B-cell chronic lymphocytic leukemia.
|
14499696 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Characterization of FAM10A4, a member of the ST13 tumor suppressor gene family that maps to the 13q14.3 region associated with B-Cell leukemia, multiple myeloma, and prostate cancer.
|
12079276 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In some cell lines, p48 was detected in the nucleus whereas in others it was cytoplasmic, as in one human acinar tumor.
|
10768861 |
2000 |
|
Colorectal Carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
The transcript level of ST13 in different CRC cell lines was evaluated by quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR).
|
23125081 |
2012 |
|
Colorectal Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
In addition to the CRC specificity, the antitumor effect of Ad·(ST13)·CEA·E1A(Δ24) was also excellent and got nearly complete inhibition (not eradication) of CRC xenograft since ST13 was an effective antitumor gene with less toxicity, and a Chinese patent (No.
|
23077639 |
2012 |
|
Colorectal Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
ST13, a co-factor of heat shock protein, has shown potential antitumor efficacy for colorectal cancer in our previous study.
|
20512919 |
2010 |
|
Colorectal Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Potent antitumor activity of double-regulated oncolytic adenovirus-mediated ST13 for colorectal cancer.
|
19298599 |
2009 |
|
Colorectal Carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
In summary, overexpressed ST13 as mediated by oncolytic adenovirus could exert potent antitumor activity via the intrinsic apoptotic pathway and has the potential to become a novel therapeutic for colorectal cancer gene therapy.
|
18355116 |
2008 |
|
Colorectal Carcinoma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
The HIP gene encoding a heparin/heparan sulfate interacting protein is mutated in metastatic human colorectal cancer.
|
12632100 |
2003 |
|
Colorectal Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
HIP is a candidate marker of abnormal cell growth in the colon and a prognostic marker for colorectal carcinoma.
|
10383165 |
1999 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
In addition, P48 could effectively block the particular signaling pathways of FGFR1 and lead to the inhibition of cancer proliferation, invasion in vitro and restraint of tumor growth in vivo.
|
31841696 |
2020 |
|
Malignant Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
HOP mRNA and protein levels were significantly higher in GC tissues than in normal tissues in our medical center (P< 0.001) and in The Cancer Genome Atlas database (P< 0.001).
|
29843139 |
2018 |
|
Malignant Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
We also demonstrate that primary human cancers contain high levels of phosphorylated chaperones and show increased levels of HOP protein and mRNA.
|
22824801 |
2013 |