ST14, suppression of tumorigenicity 14, 6768

N. diseases: 170; N. variants: 9
Disease: Crohn Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.020 AlteredExpression disease BEFREE Matriptase protein and ST14 mRNA levels are significantly downregulated in inflamed colonic tissues from Crohn's disease and ulcerative colitis patients. 22081509 2012
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.020 AlteredExpression disease BEFREE Both matriptase and prostasin are significantly down-regulated in colonic tissues from human subjects with active ulcerative colitis or Crohn's disease, implicating the loss of this barrier-protective protease pathway in the pathogenesis of irritable bowel disease. 28490634 2017