Protein expression of STAT1, HLA-class II, and CXCL10 was analyzed by digital IHC.<b>Results:</b> The Th1-centric co-ordinate immune response cluster (CIRC) was significantly, albeit modestly, reduced in <i>KRAS</i>-mutant colorectal cancer in both datasets.
Our findings suggest that STAT1 plays a role as a tumor suppressor molecule in inflammation-associated carcinogenesis, particularly during the very early stages of CAC initiation, modulating immune responses as well as controlling mechanisms such as apoptosis and cell proliferation.
Taken together, our findings shed new light on the STAT1/miR-181a/PTEN pathway in colorectal cancer and add new insight regarding the carcinogenesis of colorectal cancer..
Thus, our study indicates that the high level of IL-35 in colorectal cancer promotes the production of IL-35 via STAT1 and STAT3, which suppresses T cell proliferation and may participate in tumor immunotolerance.