Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection.
|
18438405 |
2008 |
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
CTD_human |
Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection.
|
18438405 |
2008 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection.
|
18438405 |
2008 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
By contrast, variation in the gene encoding the interleukin-23 (IL-23) receptor subunit, as well as in the IL12B, STAT3 and NKX2-3 gene regions, is associated with both Crohn's disease and ulcerative colitis.
|
18500230 |
2008 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the IL-10R1 S138G variant is a loss-of-function allele for IL-10-induced STAT1 and STAT3 activation but does not protect from UC susceptibility.
|
18800073 |
2009 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies indicate that IL23R and five additional genes involved in Th17 differentiation (IL12B, JAK2, STAT3, CCR6 and TNFSF15) are associated with susceptibility to Crohn's disease and partly also to ulcerative colitis.
|
19592695 |
2009 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In the adaptive immune response, IL23R, MST1, IL12B, and STAT3 polymorphisms are associated with Crohn's disease and ulcerative colitis.
|
19647622 |
2009 |
Ulcerative Colitis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis.
|
19926618 |
2010 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The originally described association of IBD with STAT3 polymorphisms is corroborated for the two clinical phenotypes, CD and UC, in an independent population.
|
20200543 |
2010 |
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
CTD_human |
Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
|
20228799 |
2010 |
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Inhibition of ulcerative colitis in mice after oral administration of a polyphenol-enriched cocoa extract is mediated by the inhibition of STAT1 and STAT3 phosphorylation in colon cells.
|
21574661 |
2011 |
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Other than genetic variants of IL-10 receptors, IL-10 and STAT3 genes are also associated with IBD, emphasizing the involvement of the IL-10 signalling cascade in the pathogenesis of CD and UC.
|
21631466 |
2012 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our data confirm the association between JAK2 rs10758669 (p = 0.026, OR = 1.25, 95% CI = 1.04-1.50) and STAT3 rs744166 (p = 0.04, OR = 0.83, 95% CI = 0.688-0.998) with CD, but not UC.
|
22065112 |
2012 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Data on genetic interaction reveals that the above JAK2 and STAT3 risk alleles contribute to CD susceptibility in combination with each other (OR: 2.218; 95% CI: 1.097-4.487; P = 0.024), while the JAK2 variant shows a tendency to confer UC risk only on a wild-type STAT3 background (OR: 1.997, 95%CI: 0.994-4.009, P = 0.049).
|
22269120 |
2012 |
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Interleukin-6 induces S100A9 expression in colonic epithelial cells through STAT3 activation in experimental ulcerative colitis.
|
22962574 |
2012 |
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
DAPK as a negative regulator of STAT3 emerges as therapeutic option in the treatment of ulcerative colitis and UCC.
|
23438478 |
2013 |
Ulcerative Colitis
|
0.500 |
PosttranslationalModification
|
disease |
BEFREE |
Levels of miR-124 were decreased, whereas levels of STAT3 phosphorylation increased in colon tissues from pediatric patients with active UC compared with those with inactive disease.
|
23856509 |
2013 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our study implies that the STAT3 rs2293152 polymorphism may be associated with the occurrence of UC and might be used as a predictive factor for UC in the Chinese Han population.
|
24781989 |
2014 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The results indicated that the STAT3 rs744166 polymorphism was associated with CD and UC susceptibility (CD: GA+AA vs. GG, OR = 1.20, 95%CI, 1.11-1.30, I2 = 0%, Punadjusted<0.00001, PBonferroni<0.00005, PFDR<0.00001; UC: GA+AA vs. GG, OR = 1.21, 95%CI, 1.08-1.36, I2 = 1%, Punadjusted = 0.001, PBonferroni = 0.005, PFDR = 0.00125).
|
25286337 |
2014 |
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
We investigated whether high SOCS3 increased risk for relapse through violating STAT3-dependent protective effects of interleukin (IL)-22 during UC remission.
|
25545374 |
2015 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Targeting miR-124 and STAT3 represents a novel approach for treating ulcerative colitis.
|
27709266 |
2017 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This is the first study of the single marker association of IL23R, JAK2, and STAT3 polymorphisms with ulcerative colitis and Crohn's disease in a Turkish population.
|
27852544 |
2016 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
|
28067908 |
2017 |