leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
As such, this study demonstrates that cirmtuzumab can inhibit leukemia cell activation of both NF-κB and STAT3 in patients with CLL.
|
31409670 |
2019 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Greater STAT3 (p = 0.019) and leukaemia inhibitory factor receptor (p = 0.042) protein expression was observed in treated than untreated NOK cell lines.
|
31071674 |
2019 |
leukemia
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
SD-36 achieves nanomolar cell growth inhibitory activity in leukemia and lymphoma cell lines with high levels of phosphorylated STAT3.
|
31747516 |
2019 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Induced degradation of STAT3 results in a strong suppression of its transcription network in leukemia and lymphoma cells.
|
31715132 |
2019 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
This review focuses on the role of STAT3 in pathogenesis i.e., proliferation, differentiation, migration, and apoptosis of hematological malignancies viz. leukemia, lymphoma and myeloma, and briefly highlights the potential therapeutic approaches developed against STAT3 activation pathway.
|
30217007 |
2018 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
High STAT3 expression in leukemia has been associated with an increased risk for relapse and decreased overall survival.
|
29164994 |
2018 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this review, the roles of STAT3 in the pathogenesis, diagnosis, treatment and prognosis of leukemia are discussed in the aspects of cell proliferation, differentiation and apoptosis, with the aim to further clarify the roles of STAT3 in leukemia, and shed light into possible novel targets and strategies for clinical diagnosis and treatment.
|
29749432 |
2018 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The cytokine leukaemia inhibitory factor (LIF) promotes self-renewal of mouse embryonic stem cells (ESCs) through activation of the transcription factor Stat3.
|
30154213 |
2018 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Pimozide also exerts chemotherapy and radiotherapy-sensitizing effects in cancer cells and acts as an inhibitor of STAT-3 and STAT-5 signaling proteins with potential activity in leukemia, liver and prostate cancer.
|
29958636 |
2018 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In vivo, Wogonin potentiated the inhibitory effect of ADR on leukemia development by suppressing pY705-Stat3 and Nrf2 signaling.
|
28150717 |
2017 |
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Cell size variations of large granular lymphocyte leukemia: Implication of a small cell subtype of granular lymphocyte leukemia with STAT3 mutations.
|
27064362 |
2016 |
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We studied the longitudinal kinetics of those expansions, their relationship to clinical events, and their phenotypic and molecular features, including recently reported CTL leukaemia-STAT3 mutations.
|
26728704 |
2016 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The antitumor efficacy of this strategy is further enhanced in immunocompetent mice by combining direct leukemia-specific cytotoxicity with immunogenic effects of STAT3 blocking/TLR9 triggering.
|
26796361 |
2016 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of STAT3 phosphorylation enhances tumoricidal effect of IL-15-activated dendritic cell against doxorubicin-resistant lymphoma and leukemia via TNF-α.
|
26255115 |
2015 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here we investigated the STAT3/myeloid cell leukemia 1 (MCL1) signaling pathway as a target to overcome the resistance of glioma cells to the Bcl-2-inhibiting synthetic BH3 mimetic ABT-737.
|
26297434 |
2015 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
STAT3 inhibitors: finding a home in lymphoma and leukemia.
|
24705981 |
2014 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, STAT3 inhibition represents a promising possible therapeutic strategy for the treatment of TEL-AML1 leukemia.
|
23741012 |
2013 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway, STAT3 is one of the most prominent prognosis factors for cancer and leukemia.
|
22376160 |
2012 |
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genotype analyses showed that two SNPs, namely rs17886724 and rs2293157 located in STAT3 and STAT5, respectively, were significantly associated with leukemia (p < 0.05 for all).
|
22126101 |
2012 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Hyperphosphorylation at the Y705 residue of signal transducer and activator of transcription 3 (STAT3) is implicated in tumorigenesis of leukemia and some solid tumors.
|
21840932 |
2011 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
These data further demonstrated that Stat3 plays a critical role in human leukemia HL-60 cell apoptosis and proliferation.
|
21756540 |
2011 |
leukemia
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Our data indicate that resveratrol contributes to inhibiting growth, inducing apoptosis and cell cycle arrest in the three leukemia cell lines (Jurkat, SUP-B15, and Kasumi-1), and reducing the phosphorylation of STAT3, meanwhile modulating the expression of Bcl-2 and Bax.
|
19796711 |
2010 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Blocking STAT3 function induced apoptosis in the transgenic leukemia cells but not in controls.
|
19074878 |
2008 |
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
STAT3 expression was increased in the leukemia cells from our transgenics but not in control cells.
|
19074878 |
2008 |
leukemia
|
0.400 |
Biomarker
|
disease |
LHGDN |
Trophoblast invasion: tuning through LIF, signalling via Stat3.
|
15837065 |
2005 |