|
Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The results show that dasatinib exerts synergistic effects with cisplatin in human medulloblastoma cells through the inhibition of STAT3 and Src.
|
30332965 |
2019 |
|
Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Together these data identify STAT3 as a key molecule underpinning the sexual dimorphism in medulloblastoma.
|
31683879 |
2019 |
|
Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, it also upregulated the expression of phosphorylated STAT3, indicating that the IL‑6/GP130/STAT3 pathway plays a central role in medulloblastoma.
|
29207075 |
2018 |
|
Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, combination therapy with S3-NTDi and cisplatin significantly decreased highly aggressive MYC-amplified MB cell growth and induced apoptosis by downregulating STAT3 regulated proliferation and anti-apoptotic gene expression.
|
29280516 |
2018 |
|
Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The signal transducers and activators of transcription-3 (STAT3) pathway are selectively activated in CD133<sup>+</sup> MBSCs and promote tumorigenesis through regulation of c-MYC, a key genetic driver of Group 3 MB.
|
27775079 |
2017 |
|
Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In line with these findings we show for MYC-amplified medulloblastoma a profound reduction in activity of the oncogenes STAT3 and AKT.
|
28159923 |
2017 |
|
Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In resveratrol-suppressed medulloblastoma cells with STAT3 downregulation and decreased incidence of STAT3 nuclear translocation, PIAS3 is upregulated, the SHP2 level remains unchanged and SOCS3 is downregulated.
|
28035977 |
2016 |
|
Medulloblastoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
LY5 inhibited persistent STAT3 phosphorylation and induced apoptosis in human medulloblastoma cell lines expressing constitutive STAT3 phosphorylation.
|
25313399 |
2015 |
|
Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together our studies further reveal that STAT3 plays a key role in SPARC induced G2/M arrest in medulloblastoma cells.
|
22206672 |
2012 |
|
Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results suggest that LLL12 is a potent STAT3 inhibitor and that it may be a potential therapeutic treatment for medulloblastoma and glioblastoma.
|
21526200 |
2011 |
|
Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
However, Bcl-2, a common target of STAT3 and NF-κB signaling, is distinctly up-regulated in resveratrol-treated medulloblastoma cells, indicating potential effects of NF-κB in Bcl-2 expression and anti-medulloblastoma efficiency of resveratrol.
|
21161674 |
2011 |
|
Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
High levels of activated/phosphorylated STAT3 were also present in cultured human malignant glioma and medulloblastoma cells.
|
18829483 |
2008 |
|
Medulloblastoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Sorafenib inhibits signal transducer and activator of transcription 3 signaling associated with growth arrest and apoptosis of medulloblastomas.
|
19001435 |
2008 |
|
Medulloblastoma
|
0.400 |
Biomarker
|
disease |
LHGDN |
To further ascertain the significance of STAT3 signaling for medulloblastoma cells, AG490, a selective inhibitor of STAT3 phosphorylation, was used to treat UW228-3 cells.
|
18592012 |
2008 |
|
Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Inhibition of STAT3 expression and signaling in resveratrol-differentiated medulloblastoma cells.
|
18592012 |
2008 |