Multiple Sclerosis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
We suggested that STAT3 and its associated molecules might be differentially expressed and regulated in MS patients with different genetic background.
|
31713760 |
2020 |
Multiple Sclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies (GWAS) have revealed numerous MS-risk alleles in the IL-6/STAT3, IL-12/STAT4, and IL-23/STAT3-pathways implicated in the differentiation of Th1 and Th17 cells.
|
30917537 |
2019 |
Multiple Sclerosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
In conclusion, let-7f-5p functions as a potential inhibitor of Th17 differentiation in the pathogenesis of MS by targeting STAT3 and may serve as a new therapeutic target.
|
31326963 |
2019 |
Multiple Sclerosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
A comprehensive MS-specific miRNA-TF co-regulatory network was hypothesized; among others, SP1, RELA, NF-κB, TP53, AR, MYC, HDAC1, and STAT3 regulated the transcription of 61 targets.
|
30463275 |
2018 |
Multiple Sclerosis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Gas6 stimulation also resulted in activation of STAT3 in optic nerves as well as downregulation of multiple genes involved in MS development, including matrix metalloproteinase-9 (MMP9), which may decrease the integrity of the blood-brain barrier and is found upregulated in MS lesions.
|
27630207 |
2016 |
Multiple Sclerosis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Phosphorylated STAT3 expression was also detected by Western blotting in WM of patients with MS.
|
24226263 |
2013 |
Multiple Sclerosis
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.
|
24076602 |
2013 |
Multiple Sclerosis
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
21833088 |
2011 |
Multiple Sclerosis
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
|
22190364 |
2011 |
Multiple Sclerosis
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
|
22190364 |
2011 |
Multiple Sclerosis
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
21833088 |
2011 |
Multiple Sclerosis
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene.
|
20159113 |
2010 |
Multiple Sclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The protective haplotype for MS in STAT3 is a risk allele for Crohn disease, implying that STAT3 represents a shared risk locus for at least two autoimmune diseases.
|
20159113 |
2010 |
Multiple Sclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the STAT3 region (rs3809758/rs744166/rs1026916/rs12948909) were genotyped and the inferred haplotypes were subsequently analyzed in 860 IBD and 1540 MS Spanish patients and 1720 ethnically matched controls.
|
20200543 |
2010 |
Multiple Sclerosis
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene.
|
20159113 |
2010 |
Multiple Sclerosis
|
0.200 |
PosttranslationalModification
|
disease |
BEFREE |
These findings indicated that curcumin amelioration EAE was, to a large extent, due to inhibit differentiation and development of Th17 cells depends on down-regulating expression of IL-6, IL-21, RORgammat signaling and inhibition STAT3-phosphorylation, suggests it is useful in the treatment of MS and other Th17 cell-mediated inflammatory diseases.
|
19539560 |
2009 |
Multiple Sclerosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Phosphorylated STAT3 and the anti-apoptotic molecule, Bcl2, known down stream products of CNTF signalling were also increased in MS cortical neurons.
|
17898009 |
2007 |
Multiple Sclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Several observations suggest that the interferon system may be of interest in the study of MS development To investigate whether polymorphism in components of the IFN system and the JAK-STAT pathway influence susceptibility to MS, we performed a linkage analysis between polymorphic loci in or close to the IFN gamma, IFN gamma receptor, IFN alpha/beta receptor, JAK 1, STAT 1 and STAT 3 genes in 27 Swedish families with at least two members having MS. Tests for transmission disequilibrium and nonparametric linkage analysis gave negative results.
|
14760959 |
2004 |