Pancreatic Neoplasm
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Computational STAT3 activity inference reveals its roles in the pancreatic tumor microenvironment.
|
31796877 |
2019 |
Pancreatic Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
We have previously demonstrated that anti-CD44s H4C4 or liposomal-delivered STAT3 inhibitor FLLL32 sensitized pancreatic cancer cells to radiotherapy through the elimination or inhibition of cancer stem cells (CSCs) and that HAb18G/CD147 promoted STAT3-mediated pancreatic tumor development by forming a signaling complex with CD44s.
|
31312365 |
2019 |
Pancreatic Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Blockage of STAT3 Signaling Pathway by Morusin Induces Apoptosis and Inhibits Invasion in Human Pancreatic Tumor Cells.
|
26646273 |
2016 |
Pancreatic Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
The findings implicate epithelial tension and matricellular fibrosis in the aggressiveness of SMAD4 mutant pancreatic tumors and highlight STAT3 and mechanics as key drivers of this phenotype.
|
27089513 |
2016 |
Pancreatic Neoplasm
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Stat3, Il6st (encodes gp130), or Trp53 were disrupted, or a mutant form of P53 (P53R172H) or transgenic sgp130 were expressed, in mice that developed pancreatic tumors resulting from expression of activated KRAS (KrasG12D, KC mice).
|
27003603 |
2016 |
Pancreatic Neoplasm
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Inflammatory molecules NF-κB and STAT3 are overexpressed in pancreatic tumors.
|
24520096 |
2014 |
Pancreatic Neoplasm
|
0.400 |
Biomarker
|
disease |
CTD_human |
Andrographolide causes apoptosis via inactivation of STAT3 and Akt and potentiates antitumor activity of gemcitabine in pancreatic cancer.
|
23845849 |
2013 |
Pancreatic Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Additional inhibition of PI3K and STAT3 effectively prevented proliferation of explants derived from these p53-defective pancreatic tumors.
|
22975375 |
2012 |
Pancreatic Neoplasm
|
0.400 |
Biomarker
|
disease |
CTD_human |
EGCG enhances the therapeutic potential of gemcitabine and CP690550 by inhibiting STAT3 signaling pathway in human pancreatic cancer.
|
22348037 |
2012 |
Pancreatic Neoplasm
|
0.400 |
Biomarker
|
disease |
LHGDN |
In mice that were fed BITC (60 micromol/wk, five mice, 10 tumors per group), growth of BxPC-3 pancreatic tumor xenografts was suppressed compared with control mice (at 6 weeks, mean tumor volume of control vs BITC-treated mice = 334 vs 172 mm3, difference =162 mm3, 95% confidence interval = 118 to 204 mm3; P = .008) and tumors had increased apoptosis and reduced STAT-3 protein expression.
|
19176463 |
2009 |
Pancreatic Neoplasm
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Mesothelin-induced pancreatic cancer cell proliferation involves alteration of cyclin E via activation of signal transducer and activator of transcription protein 3.
|
19010822 |
2008 |
Pancreatic Neoplasm
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
RNA interference-mediated signal transducers and activators of transcription 3 gene silencing inhibits invasion and metastasis of human pancreatic cancer cells.
|
17459060 |
2007 |
Pancreatic Neoplasm
|
0.400 |
Biomarker
|
disease |
LHGDN |
Targeting heat shock protein 90 in pancreatic cancer impairs insulin-like growth factor-I receptor signaling, disrupts an interleukin-6/signal-transducer and activator of transcription 3/hypoxia-inducible factor-1alpha autocrine loop, and reduces orthotopic tumor growth.
|
17975158 |
2007 |
Pancreatic Neoplasm
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis.
|
12545153 |
2003 |